Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies
Joint Authors
de Souza, Heitor S.
Bernardazzi, Claudio
Nunes, Tiago
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity.
IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract.
In addition, it has been proposed that IL-33 can act as a signaling molecule alerting the immune system of danger or tissue damage.
Recently, in the intestinal mucosa, overexpression of IL-33 has been reported in samples from patients with inflammatory bowel diseases (IBD).
This review highlights the available data regarding IL-33 in human IBD and discusses emerging roles for IL-33 as a key modulator of intestinal inflammation.
American Psychological Association (APA)
Nunes, Tiago& Bernardazzi, Claudio& de Souza, Heitor S.. 2014. Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043553
Modern Language Association (MLA)
Nunes, Tiago…[et al.]. Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043553
American Medical Association (AMA)
Nunes, Tiago& Bernardazzi, Claudio& de Souza, Heitor S.. Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043553
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043553
