H. pylori Virulence Factors: Influence on Immune System and Pathology
Joint Authors
Kalali, Behnam
Mejías-Luque, Raquel
Javaheri, Anahita
Gerhard, Markus
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Helicobacter pylori is the most widespread chronic bacterial agent in humans and is well recognized for its association with ulcer disease and gastric cancer, with both representing major global health and socioeconomic issues.
Given the high level of adaptation and the coevolution of this bacterium with its human host, a thorough and multidirectional view of the specific microbiological characteristics of this infection as well as the host physiology is needed in order to develop novel means of prevention of therapy.
This review aims to pinpoint some of these potentially important angles, which have to be considered mutually when studying H.
pylori’s pathogenicity.
The host’s biological changes due to the virulence factors are a valuable pillar of H.
pylori research as are the mechanisms by which bacteria provoke these changes.
In this context, necessary adhesion molecules and significant virulence factors of H.
pylori are discussed.
Moreover, metabolism of the bacteria, one of the most important aspects for a better understanding of bacterial physiology and consequently possible therapeutic and prophylactic strategies, is addressed.
On the other hand, we discuss the recent experimental proofs of the “hygiene hypothesis” in correlation with Helicobacter’s infection, which adds another aspect of complexity to this infection.
American Psychological Association (APA)
Kalali, Behnam& Mejías-Luque, Raquel& Javaheri, Anahita& Gerhard, Markus. 2013. H. pylori Virulence Factors: Influence on Immune System and Pathology. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043556
Modern Language Association (MLA)
Kalali, Behnam…[et al.]. H. pylori Virulence Factors: Influence on Immune System and Pathology. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043556
American Medical Association (AMA)
Kalali, Behnam& Mejías-Luque, Raquel& Javaheri, Anahita& Gerhard, Markus. H. pylori Virulence Factors: Influence on Immune System and Pathology. Mediators of Inflammation. 2013. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043556