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Role of Microglia Adenosine A2A Receptors in Retinal and Brain Neurodegenerative Diseases
Joint Authors
Santiago, Ana R.
Baptista, Filipa I.
Santos, Paulo F.
Cristóvão, Gonçalo
Ambrósio, António F.
Cunha, Rodrigo A.
Gomes, Catarina A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Neuroinflammation mediated by microglial cells in the brain has been commonly associated with neurodegenerative diseases.
Whether this microglia-mediated neuroinflammation is cause or consequence of neurodegeneration is still a matter of controversy.
However, it is unequivocal that chronic neuroinflammation plays a role in disease progression and halting that process represents a potential therapeutic strategy.
The neuromodulator adenosine emerges as a promising targeting candidate based on its ability to regulate microglial proliferation, chemotaxis, and reactivity through the activation of its G protein coupled A 2A receptor ( A 2 A R ).
This is in striking agreement with the ability of A 2 A R blockade to control several brain diseases.
Retinal degenerative diseases have been also associated with microglia-mediated neuroinflammation, but the role of A 2 A R has been scarcely explored.
This review aims to compare inflammatory features of Parkinson’s and Alzheimer’s diseases with glaucoma and diabetic retinopathy, discussing the therapeutic potential of A 2 A R in these degenerative conditions.
American Psychological Association (APA)
Santiago, Ana R.& Baptista, Filipa I.& Santos, Paulo F.& Cristóvão, Gonçalo& Ambrósio, António F.& Cunha, Rodrigo A.…[et al.]. 2014. Role of Microglia Adenosine A2A Receptors in Retinal and Brain Neurodegenerative Diseases. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043575
Modern Language Association (MLA)
Santiago, Ana R.…[et al.]. Role of Microglia Adenosine A2A Receptors in Retinal and Brain Neurodegenerative Diseases. Mediators of Inflammation No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043575
American Medical Association (AMA)
Santiago, Ana R.& Baptista, Filipa I.& Santos, Paulo F.& Cristóvão, Gonçalo& Ambrósio, António F.& Cunha, Rodrigo A.…[et al.]. Role of Microglia Adenosine A2A Receptors in Retinal and Brain Neurodegenerative Diseases. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043575