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Importins and Exportins Regulating Allergic Immune Responses
Joint Authors
Aggarwal, Ankita
Agrawal, Devendra K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Nucleocytoplasmic shuttling of macromolecules is a well-controlled process involving importins and exportins.
These karyopherins recognize and bind to receptor-mediated intracellular signals through specific signal sequences that are present on cargo proteins and transport into and out of the nucleus through nuclear pore complexes.
Nuclear localization signals (NLS) present on cargo molecules to be imported while nuclear export signals (NES) on the molecules to be exported are recognized by importins and exportins, respectively.
The classical NLS are found on many transcription factors and molecules that are involved in the pathogenesis of allergic diseases.
In addition, several immune modulators, including corticosteroids and vitamin D, elicit their cellular responses by regulating the expression and activity of importin molecules.
In this review article, we provide a comprehensive list of importin and exportin molecules and their specific cargo that shuttled between cytoplasm and the nucleus.
We also critically review the role and regulation of specific importin and exportin involved in the transport of activated transcription factors in allergic diseases, the underlying molecular mechanisms, and the potential target sites for developing better therapeutic approaches.
American Psychological Association (APA)
Aggarwal, Ankita& Agrawal, Devendra K.. 2014. Importins and Exportins Regulating Allergic Immune Responses. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043586
Modern Language Association (MLA)
Aggarwal, Ankita& Agrawal, Devendra K.. Importins and Exportins Regulating Allergic Immune Responses. Mediators of Inflammation No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1043586
American Medical Association (AMA)
Aggarwal, Ankita& Agrawal, Devendra K.. Importins and Exportins Regulating Allergic Immune Responses. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043586