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Chemokine CXCL16 Expression Suppresses Migration and Invasiveness and Induces Apoptosis in Breast Cancer Cells
Joint Authors
Fang, Yeying
Henderson, Fraser C.
Yi, Qiong
Lei, Qianqian
Li, Yan
Chen, Nianyong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Increasing evidence argues that soluble CXCL16 promotes proliferation, migration, and invasion of cancer cells in vitro.
However, the role of transmembrane or cellular CXCL16 in cancer remains relatively unknown.
In this study, we determine the function of cellular CXCL16 as tumor suppressor in breast cancer cells.
Methods.
Expression of cellular CXCL16 in breast cancer cell lines was determined at both RNA and protein levels.
In vitro and in vivo studies that overexpressed or downregulated CXCL16 were conducted in breast cancer cells.
Results.
We report differential expression of cellular CXCL16 in breast cancer cell lines that was negatively correlated with cell invasiveness and migration.
Overexpression of CXCL16 in MDA-MB-231 cells led to a decrease in cell invasion and migration and induced apoptosis of the cells; downregulation of CXCL16 in MCF-7 cells increased cell migration and invasiveness.
Consistent with the in vitro data, CXCL16 overexpression inhibited tumorigenesis in vivo.
Conclusions.
Cellular CXCL16 suppresses invasion and metastasis of breast cancer cells in vitro and inhibits tumorigenesis in vivo.
Targeting of cellular CXCL16 expression is a potential therapeutic strategy for breast cancer.
American Psychological Association (APA)
Fang, Yeying& Henderson, Fraser C.& Yi, Qiong& Lei, Qianqian& Li, Yan& Chen, Nianyong. 2014. Chemokine CXCL16 Expression Suppresses Migration and Invasiveness and Induces Apoptosis in Breast Cancer Cells. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043588
Modern Language Association (MLA)
Fang, Yeying…[et al.]. Chemokine CXCL16 Expression Suppresses Migration and Invasiveness and Induces Apoptosis in Breast Cancer Cells. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043588
American Medical Association (AMA)
Fang, Yeying& Henderson, Fraser C.& Yi, Qiong& Lei, Qianqian& Li, Yan& Chen, Nianyong. Chemokine CXCL16 Expression Suppresses Migration and Invasiveness and Induces Apoptosis in Breast Cancer Cells. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043588