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TLR4-Mediated Blunting of Inflammatory Responses to Eccentric Exercise in Young Women
Joint Authors
González-Gallego, Javier
Fernandez-Gonzalo, Rodrigo
De Paz, José A.
Rodriguez-Miguelez, Paula
Cuevas, María J.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study assessed the inflammatory response mediated by the toll-like receptor 4 (TLR4) signaling pathway after acute eccentric exercise before and after an eccentric training program in women.
Twenty women performed two acute eccentric bouts using a squat machine over a ~9 week interval.
The training group (TG) carried out an eccentric training program during 6 weeks, while the control group (CG) did not follow any training.
Protein content of markers involved in the TLR4-mediated activation of several nuclear transcription factors, such as nuclear factor κB (NF-κB), and interferon regulatory transcription factor 3 (IRF3), was analyzed.
The inflammatory response after the first acute bout was similar between TG and CG, showing an upregulation of all the markers analyzed, with the exception of IRF3.
After the second bout, the upregulation of TLR4 signaling pathway was blunted in TG, but not in CG, through both the myeloid differentiation factor 88- and toll/interleukin-1 receptor domain containing adapter inducing interferon-β-dependent pathways.
These results highlight the role of the TLR4 in controlling the exercise-induced inflammatory response in young women.
More importantly, these data suggest eccentric training may help to prevent TLR4 activation principally through NF-κB, and perhaps IRF3, downstream signaling in this population.
American Psychological Association (APA)
Fernandez-Gonzalo, Rodrigo& De Paz, José A.& Rodriguez-Miguelez, Paula& Cuevas, María J.& González-Gallego, Javier. 2014. TLR4-Mediated Blunting of Inflammatory Responses to Eccentric Exercise in Young Women. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043589
Modern Language Association (MLA)
Fernandez-Gonzalo, Rodrigo…[et al.]. TLR4-Mediated Blunting of Inflammatory Responses to Eccentric Exercise in Young Women. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043589
American Medical Association (AMA)
Fernandez-Gonzalo, Rodrigo& De Paz, José A.& Rodriguez-Miguelez, Paula& Cuevas, María J.& González-Gallego, Javier. TLR4-Mediated Blunting of Inflammatory Responses to Eccentric Exercise in Young Women. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043589