IL-21 Receptor Expression in Human Tendinopathy
Joint Authors
Campbell, Abigail L.
Smith, Nicola C.
Reilly, James H.
Kerr, Shauna C.
Leach, William J.
Fazzi, Umberto G.
Rooney, Brian P.
Murrell, George A. C.
Millar, Neal L.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role.
Increasing evidence points toward an early inflammatory infiltrate and associated inflammatory cytokine production in human and animal models of tendon disease.
The IL-21/IL-21R axis is a proinflammatory cytokine complex that has been associated with chronic inflammatory diseases including rheumatoid arthritis and inflammatory bowel disease.
This project aimed to investigate the role and expression of the cytokine/receptor pair IL-21/IL-21R in human tendinopathy.
We found significantly elevated expression of IL-21 receptor message and protein in human tendon samples but found no convincing evidence of the presence of IL-21 at message or protein level.
The level of expression of IL-21R message/protein in human tenocytes was significantly upregulated by proinflammatory cytokines (TNFα/IL-1β) in vitro.
These findings demonstrate that IL-21R is present in early human tendinopathy mainly expressed by tenocytes and macrophages.
Despite a lack of IL-21 expression, these data again suggest that early tendinopathy has an inflammatory/cytokine phenotype, which may provide novel translational targets in the treatment of tendinopathy.
American Psychological Association (APA)
Campbell, Abigail L.& Smith, Nicola C.& Reilly, James H.& Kerr, Shauna C.& Leach, William J.& Fazzi, Umberto G.…[et al.]. 2014. IL-21 Receptor Expression in Human Tendinopathy. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043592
Modern Language Association (MLA)
Campbell, Abigail L.…[et al.]. IL-21 Receptor Expression in Human Tendinopathy. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043592
American Medical Association (AMA)
Campbell, Abigail L.& Smith, Nicola C.& Reilly, James H.& Kerr, Shauna C.& Leach, William J.& Fazzi, Umberto G.…[et al.]. IL-21 Receptor Expression in Human Tendinopathy. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043592