Bone Remodelling Markers in Rheumatoid Arthritis
Joint Authors
Goëb, Vincent
Fardellone, Patrice
Séjourné, Alice
Paccou, Julien
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Bone loss in rheumatoid arthritis (RA) patients results from chronic inflammation and can lead to osteoporosis and fractures.
A few bone remodeling markers have been studied in RA witnessing bone formation (osteocalcin), serum aminoterminal propeptide of type I collagen (PINP), serum carboxyterminal propeptide of type I collagen (ICTP), bone alkaline phosphatase (BAP), osteocalcin (OC), and bone resorption: C-terminal telopeptide of type 1 collagen (I-CTX), N-terminal telopeptide of type 1 collagen (I-NTX), pyridinolines (DPD and PYD), and tartrate-resistant acid phosphatase (TRAP).
Bone resorption can be seen either in periarticular bone (demineralization and erosion) or in the total skeleton (osteoporosis).
Whatever the location, bone resorption results from activation of osteoclasts when the ratio between osteoprotegerin and receptor activator of nuclear factor kappa-B ligand (OPG/RANKL) is decreased under influence of various proinflammatory cytokines.
Bone remodeling markers also allow physicians to evaluate the effect of drugs used in RA like biologic agents, which reduce inflammation and exert a protecting effect on bone.
We will discuss in this review changes in bone markers remodeling in patients with RA treated with biologics.
American Psychological Association (APA)
Fardellone, Patrice& Séjourné, Alice& Paccou, Julien& Goëb, Vincent. 2014. Bone Remodelling Markers in Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043595
Modern Language Association (MLA)
Fardellone, Patrice…[et al.]. Bone Remodelling Markers in Rheumatoid Arthritis. Mediators of Inflammation No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1043595
American Medical Association (AMA)
Fardellone, Patrice& Séjourné, Alice& Paccou, Julien& Goëb, Vincent. Bone Remodelling Markers in Rheumatoid Arthritis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043595