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Calpain Activity and Toll-Like Receptor 4 Expression in Platelet Regulate Haemostatic Situation in Patients Undergoing Cardiac Surgery and Coagulation in Mice
Joint Authors
Lin, Feng-Yen
Tsai, Jui-Chi
Lin, Yi-Wen
Huang, Chun-Yao
Tsai, Chien-Sung
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Human platelets express Toll-like receptors (TLR) 4.
However, the mechanism by which TLR4 directly affects platelet aggregation and blood coagulation remains to be explored.
Therefore, in this study, we evaluated the platelet TLR4 expression in patients who underwent CABG surgery; we explored the correlation between platelet TLR4 expression and the early outcomes in hospital of patients.
Additionally, C57BL/6 and C57BL/6-TlrLPS−/− mice were used to explore the roles of platelet TLR4 in coagulation by platelet aggregometry and rotation thromboelastometry.
In conclusion, our results highlight the important roles of TLR4 in blood coagulation and platelet function.
Of clinical relevance, we also explored novel roles for platelet TLR4 that are associated with early outcomes in cardiac surgery.
American Psychological Association (APA)
Tsai, Jui-Chi& Lin, Yi-Wen& Huang, Chun-Yao& Lin, Feng-Yen& Tsai, Chien-Sung. 2014. Calpain Activity and Toll-Like Receptor 4 Expression in Platelet Regulate Haemostatic Situation in Patients Undergoing Cardiac Surgery and Coagulation in Mice. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043596
Modern Language Association (MLA)
Tsai, Jui-Chi…[et al.]. Calpain Activity and Toll-Like Receptor 4 Expression in Platelet Regulate Haemostatic Situation in Patients Undergoing Cardiac Surgery and Coagulation in Mice. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043596
American Medical Association (AMA)
Tsai, Jui-Chi& Lin, Yi-Wen& Huang, Chun-Yao& Lin, Feng-Yen& Tsai, Chien-Sung. Calpain Activity and Toll-Like Receptor 4 Expression in Platelet Regulate Haemostatic Situation in Patients Undergoing Cardiac Surgery and Coagulation in Mice. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043596