Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord
Joint Authors
Liu, Suhuan
Liu, Ming
Liao, Kaijun
Yu, Changxi
Li, Xuejun
Yang, Shuyu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Neuropathic pain responds poorly to drug treatments, and partial relief is achieved in only about half of the patients.
Puerarin, the main constituent of Puerariae Lobatae Radix, has been used extensively in China to treat hypertension and tumor.
The current study examined the effects of puerarin on neuropathic pain using two most commonly used animal models: chronic constriction injury (CCI) and diabetic neuropathy.
We found that consecutive intrathecal administration of puerarin (4–100 nM) for 7 days inhibited the mechanical and thermal nociceptive response induced by CCI and diabetes without interfering with the normal pain response.
Meanwhile, in both models puerarin inhibited the activation of microglia and astroglia in the spinal dorsal horn.
Puerarin also reduced the upregulated levels of nuclear factor- κ B (NF- κ B) and other proinflammatory cytokines, such as IL-6, IL-1 β , and TNF- α , in the spinal cord.
In summary, puerarin alleviated CCI- and diabetes-induced neuropathic pain, and its effectiveness might be due to the inhibition of neuroinflammation in the spinal cord.
The anti-inflammation effect of puerarin might be related to the suppression of spinal NF- κ B activation and/or cytokines upregulation.
We conclude that puerarin has a significant effect on alleviating neuropathic pain and thus may serve as a therapeutic approach for neuropathic pain.
American Psychological Association (APA)
Liu, Ming& Liao, Kaijun& Yu, Changxi& Li, Xuejun& Liu, Suhuan& Yang, Shuyu. 2014. Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043599
Modern Language Association (MLA)
Liu, Ming…[et al.]. Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043599
American Medical Association (AMA)
Liu, Ming& Liao, Kaijun& Yu, Changxi& Li, Xuejun& Liu, Suhuan& Yang, Shuyu. Puerarin Alleviates Neuropathic Pain by Inhibiting Neuroinflammation in Spinal Cord. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043599