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Herbal Extract SH003 Suppresses Tumor Growth and Metastasis of MDA-MB-231 Breast Cancer Cells by Inhibiting STAT3-IL-6 Signaling
Joint Authors
Woo, Sang-Mi
Ko, Seong-Gyu
Shin, Yong Cheol
Cho, Sung-Gook
Park, Sunju
Choi, Youn Kyung
Yun, Yee Jin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cancer inflammation promotes cancer progression, resulting in a high risk of cancer.
Here, we demonstrate that our new herbal extract, SH003, suppresses both tumor growth and metastasis of MDA-MB-231 breast cancer cells via inhibiting STAT3-IL-6 signaling path.
Our new herbal formula, SH003, mixed extract from Astragalus membranaceus, Angelica gigas, and Trichosanthes kirilowii Maximowicz, suppressed MDA-MB-231 tumor growth and lung metastasis in vivo and reduced the viability and metastatic abilities of MDA-MB-231 cells in vitro.
Furthermore, SH003 inhibited STAT3 activation, which resulted in a reduction of IL-6 production.
Therefore, we conclude that SH003 suppresses highly metastatic breast cancer growth and metastasis by inhibiting STAT3-IL-6 signaling path.
American Psychological Association (APA)
Choi, Youn Kyung& Cho, Sung-Gook& Woo, Sang-Mi& Yun, Yee Jin& Park, Sunju& Shin, Yong Cheol…[et al.]. 2014. Herbal Extract SH003 Suppresses Tumor Growth and Metastasis of MDA-MB-231 Breast Cancer Cells by Inhibiting STAT3-IL-6 Signaling. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043600
Modern Language Association (MLA)
Choi, Youn Kyung…[et al.]. Herbal Extract SH003 Suppresses Tumor Growth and Metastasis of MDA-MB-231 Breast Cancer Cells by Inhibiting STAT3-IL-6 Signaling. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043600
American Medical Association (AMA)
Choi, Youn Kyung& Cho, Sung-Gook& Woo, Sang-Mi& Yun, Yee Jin& Park, Sunju& Shin, Yong Cheol…[et al.]. Herbal Extract SH003 Suppresses Tumor Growth and Metastasis of MDA-MB-231 Breast Cancer Cells by Inhibiting STAT3-IL-6 Signaling. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043600