Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis
Joint Authors
Ponchel, Frédérique
Burska, Agata N.
Hunt, Laura
Boissinot, Marjorie
Strollo, Rocky
Ryan, Brent J.
Vital, Ed
Nissim, Ahuva
Winyard, Paul G.
Emery, Paul
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-23
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Autoantibodies have been associated with human pathologies for a long time, particularly with autoimmune diseases (AIDs).
Rheumatoid factor (RF) is known since the late 1930s to be associated with rheumatoid arthritis (RA).
The discovery of anticitrullinated protein antibodies in the last century has changed this and other posttranslational modifications (PTM) relevant to RA have since been described.
Such PTM introduce neoepitopes in proteins that can generate novel autoantibody specificities.
The recent recognition of these novel specificities in RA provides a unique opportunity to understand human B-cell development in vivo.
In this paper, we will review the three of the main classes of PTMs already associated with RA: citrullination, carbamylation, and oxidation.
With the advancement of research methodologies it should be expected that other autoantibodies against PTM proteins could be discovered in patients with autoimmune diseases.
Many of such autoantibodies may provide significant biomarker potential.
American Psychological Association (APA)
Burska, Agata N.& Hunt, Laura& Boissinot, Marjorie& Strollo, Rocky& Ryan, Brent J.& Vital, Ed…[et al.]. 2014. Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-1043601
Modern Language Association (MLA)
Burska, Agata N.…[et al.]. Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis. Mediators of Inflammation No. 2014 (2014), pp.1-19.
https://search.emarefa.net/detail/BIM-1043601
American Medical Association (AMA)
Burska, Agata N.& Hunt, Laura& Boissinot, Marjorie& Strollo, Rocky& Ryan, Brent J.& Vital, Ed…[et al.]. Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-1043601
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043601