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Auricular Electroacupuncture Reduced Inflammation-Related Epilepsy Accompanied by Altered TRPA1, pPKCα, pPKCε, and pERk12 Signaling Pathways in Kainic Acid-Treated Rats
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Inflammation is often considered to play a crucial role in epilepsy by affecting iron status and metabolism.
In this study, we investigated the curative effect of auricular acupuncture and somatic acupuncture on kainic acid- (KA-) induced epilepsy in rats.
Methods.
We established an epileptic seizure model in rats by KA (12 mg, ip).
The 2 Hz electroacupuncture (EA) was applied at auricular and applied at Zusanli and Shangjuxu (ST36-ST37) acupoints for 20 min for 3 days/week for 6 weeks beginning on the day following the KA injection.
Results.
The electrophysiological results indicated that neuron overexcitation occurred in the KA-treated rats.
This phenomenon could be reversed among either the auricular EA or ST36-ST37 EA treatment, but not in the sham-control rats.
The Western blot results revealed that TRPA1, but not TRPV4, was upregulated by injecting KA and could be attenuated by administering auricular or ST36-ST37 EA, but not in the sham group.
In addition, potentiation of TRPA1 was accompanied by increased PKCα and reduced PKCε.
Furthermore, pERK1/2, which is indicated in inflammation, was also increased by KA.
Furthermore, the aforementioned mechanisms could be reversed by administering auricular EA and could be partially reversed by ST36-ST37 EA.
Conclusions.
These results indicate a novel mechanism for treating inflammation-associated epilepsy and can be translated into clinical therapy.
American Psychological Association (APA)
Lin, Yi-Wen& Hsieh, Ching-Liang. 2014. Auricular Electroacupuncture Reduced Inflammation-Related Epilepsy Accompanied by Altered TRPA1, pPKCα, pPKCε, and pERk12 Signaling Pathways in Kainic Acid-Treated Rats. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043603
Modern Language Association (MLA)
Lin, Yi-Wen& Hsieh, Ching-Liang. Auricular Electroacupuncture Reduced Inflammation-Related Epilepsy Accompanied by Altered TRPA1, pPKCα, pPKCε, and pERk12 Signaling Pathways in Kainic Acid-Treated Rats. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043603
American Medical Association (AMA)
Lin, Yi-Wen& Hsieh, Ching-Liang. Auricular Electroacupuncture Reduced Inflammation-Related Epilepsy Accompanied by Altered TRPA1, pPKCα, pPKCε, and pERk12 Signaling Pathways in Kainic Acid-Treated Rats. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043603