TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA
Joint Authors
Reis, Aramys Silva dos
Fernandes, Elizabeth S.
Brito, Carolina X. L.
Teixeira, Simone A.
Barboza, Renato
Azevedo-Santos, Ana Paula S.
Muscará, Marcelo
Costa, Soraia K. P.
Marinho, Claudio R. F.
Brain, Susan D.
Grisotto, Marcos A. G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Thousands of people suffer from severe malaria every year.
The innate immune response plays a determinant role in host’s defence to malaria.
Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed.
We investigated the effects of capsazepine, a TRPV1 antagonist, in malaria.
C57BL/6 mice received 105 red blood cells infected with Plasmodium berghei ANKA intraperitoneally.
Noninfected mice were used as controls.
Capsazepine or vehicle was given intraperitoneally for 6 days.
Mice were culled on day 7 after infection and blood and spleen cell phenotype and activation were evaluated.
Capsazepine decreased circulating but not spleen F4/80+Ly6G+ cell numbers as well as activation of both F4/80+and F4/80+Ly6G+ cells in infected animals.
In addition, capsazepine increased circulating but not spleen GR1+ and natural killer (NK) population, without interfering with natural killer T (NKT) cell numbers and blood NK and NKT activation.
However, capsazepine diminished CD69 expression in spleen NKT but not NK cells.
Infection increased lipid peroxidation and the release of TNFα and IFNγ, although capsazepine-treated group exhibited lower levels of lipid peroxidation and TNFα.
Capsazepine treatment did not affect parasitaemia.
Overall, TRPV1 antagonism modulates the innate immune response to malaria.
American Psychological Association (APA)
Brito, Carolina X. L.& Teixeira, Simone A.& Barboza, Renato& Reis, Aramys Silva dos& Azevedo-Santos, Ana Paula S.& Muscará, Marcelo…[et al.]. 2014. TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043620
Modern Language Association (MLA)
Brito, Carolina X. L.…[et al.]. TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043620
American Medical Association (AMA)
Brito, Carolina X. L.& Teixeira, Simone A.& Barboza, Renato& Reis, Aramys Silva dos& Azevedo-Santos, Ana Paula S.& Muscará, Marcelo…[et al.]. TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043620
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043620