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High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors
Joint Authors
Texidó, Laura
Vidal, August
Condom, Enric
Ponce, Jordi
Martín-Satué, Mireia
Aliagas, Elisabet
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
One of the strategies used by tumors to evade immunosurveillance is the accumulation of extracellular adenosine, which has immunosupressive and tumor promoting effects.
The study of the mechanisms leading to adenosine formation at the tumor interstitium are therefore of great interest in oncology.
The dominant pathway generating extracellular adenosine in tumors is the dephosphorylation of ATP by ecto-nucleotidases.
Two of these enzymes acting sequentially, CD39 and CD73, efficiently hydrolyze extracellular ATP to adenosine.
They have been found to play a crucial role in a variety of tumors, but there were no data concerning endometrial cancer, the most frequent of the invasive tumors of the female genital tract.
The aim of the present work is to study the expression of CD39 and CD73 in human endometrial cancer.
We have analyzed protein and gene expression, as well as enzyme activity, in type I endometrioid adenocarcinomas and type II serous adenocarcinomas and their nonpathological endometrial counterparts.
High levels of both enzymes were found in tumor samples, with significantly increased expression of CD39 in type II serous tumors, which also coincided with the higher tumor grade.
Our results reinforce the involvement of the adenosinergic system in cancer, emphasizing the relevance of ecto-nucleotidases as emerging therapeutic targets in oncology.
American Psychological Association (APA)
Aliagas, Elisabet& Vidal, August& Texidó, Laura& Ponce, Jordi& Condom, Enric& Martín-Satué, Mireia. 2014. High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043623
Modern Language Association (MLA)
Aliagas, Elisabet…[et al.]. High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043623
American Medical Association (AMA)
Aliagas, Elisabet& Vidal, August& Texidó, Laura& Ponce, Jordi& Condom, Enric& Martín-Satué, Mireia. High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043623
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043623