Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome
Joint Authors
Averna, Maurizio
Hopps, E.
Lo Presti, R.
Montana, M.
Canino, B.
Caimi, G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Our aim was to examine some parameters of oxidative status, gelatinases, and their inhibitors and to evaluate their interrelationships in subjects with metabolic syndrome (MS).
We enrolled 65 MS subjects, subdivided according to the presence or not of diabetes mellitus.
We examined lipid peroxidation (expressed as thiobarbituric acid reacting substances, TBARS), protein oxidation (expressed as carbonyl groups), nitric oxide metabolites (NOx), total antioxidant status (TAS), MMP-2, MMP-9, TIMP-1, and TIMP-2.
We found that MS subjects, diabetics and nondiabetics, showed an increase in TBARS, PC, and NOx.
A significant decrease in TAS was observed only in nondiabetic MS subjects in comparison with diabetic MS subjects.
We observed increased concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2, higher in diabetic subjects.
Our data showed a positive correlation between TAS and MMP-2, TAS and MMP-9, and TAS and MMP-9/TIMP-1 and a negative correlation between TBARS and MMP-2 in diabetic MS subjects in the entire group.
In MS subjects a prooxidant status and increased levels of gelatinases and their inhibitors are evident although the correlations between oxidative stress and MMPs or TIMPs are controversial and need further investigation.
American Psychological Association (APA)
Hopps, E.& Lo Presti, R.& Montana, M.& Canino, B.& Averna, Maurizio& Caimi, G.. 2014. Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043624
Modern Language Association (MLA)
Hopps, E.…[et al.]. Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043624
American Medical Association (AMA)
Hopps, E.& Lo Presti, R.& Montana, M.& Canino, B.& Averna, Maurizio& Caimi, G.. Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043624