Guidance Cue Netrin-1 and the Regulation of Inflammation in Acute and Chronic Kidney Disease
Joint Authors
Ranganathan, Punithavathi
Mohamed, Riyaz
Jayakumar, Calpurnia
Ramesh, Ganesan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Acute kidney injury (AKI) is a common problem in the hospital setting and intensive care unit.
Despite improved understanding, there are no effective therapies available to treat AKI.
A large body of evidence strongly suggests that ischemia reperfusion injury is an inflammatory disease mediated by both adaptive and innate immune systems.
Cell migration also plays an important role in embryonic development and inflammation, and this process is highly regulated to ensure tissue homeostasis.
One such paradigm exists in the developing nervous system, where neuronal migration is mediated by a balance between chemoattractive and chemorepulsive signals.
The ability of the guidance molecule netrin-1 to repulse or abolish attraction of neuronal cells expressing the UNC5B receptor makes it an attractive candidate for the regulation of inflammatory cell migration.
Recent identification of netrin-1 as regulators of immune cell migration has led to a large number of studies looking into how netrin-1 controls inflammation and inflammatory cell migration.
This review will focus on recent advances in understanding netrin-1 mediated regulation of inflammation during acute and chronic kidney disease and whether netrin-1 and its receptor activation can be used to treat acute and chronic kidney disease.
American Psychological Association (APA)
Ranganathan, Punithavathi& Mohamed, Riyaz& Jayakumar, Calpurnia& Ramesh, Ganesan. 2014. Guidance Cue Netrin-1 and the Regulation of Inflammation in Acute and Chronic Kidney Disease. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043633
Modern Language Association (MLA)
Ranganathan, Punithavathi…[et al.]. Guidance Cue Netrin-1 and the Regulation of Inflammation in Acute and Chronic Kidney Disease. Mediators of Inflammation No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043633
American Medical Association (AMA)
Ranganathan, Punithavathi& Mohamed, Riyaz& Jayakumar, Calpurnia& Ramesh, Ganesan. Guidance Cue Netrin-1 and the Regulation of Inflammation in Acute and Chronic Kidney Disease. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043633