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Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients?
Joint Authors
Dénarié, Delphine
Constant, Elodie
Thomas, Thierry
Marotte, Hubert
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The aim of this review is to clarify the usefulness of bone, cartilage, and synovial biomarker in the management of rheumatoid arthritis (RA) therapy in remission.
Synovial Biomarkers.
High MMP-3 levels are associated with joint progression in RA patients, but there is no data about their utility in clinical remission.
IIINys and Glc-Gal-PYD seem to be more specific to synovium, but more studies are required.
Cartilage Biomarkers.
Unbalance between cartilage break-down biomarkers (urinary CTX II and COMP) and cartilage formation biomarker (PIIANP) was described.
This unbalance is also associated with joint destruction and prognosis of destruction.
No data are available on patients in remission.
Bone Biomarkers.
RA activity is correlated with an increase of bone resorption markers such as CTX I, PYD, and TRACP 5b and a decrease of bone formation markers such as OC and BALP.
RA therapies seem to improve bone turnover in limiting bone resorption.
There is no study about bone marker utility in remission.
Conclusion.
Biomarkers seem to correlate with RA activity and progression.
They also could be used to manage RA therapies, but we need more data on RA remission to predict relapse.
American Psychological Association (APA)
Dénarié, Delphine& Constant, Elodie& Thomas, Thierry& Marotte, Hubert. 2014. Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients?. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043634
Modern Language Association (MLA)
Dénarié, Delphine…[et al.]. Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients?. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043634
American Medical Association (AMA)
Dénarié, Delphine& Constant, Elodie& Thomas, Thierry& Marotte, Hubert. Could Biomarkers of Bone, Cartilage or Synovium Turnover Be Used for Relapse Prediction in Rheumatoid Arthritis Patients?. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043634