Changes in Cerebrospinal Fluid Biomarkers in Human Herpesvirus-6-Associated Acute EncephalopathyFebrile Seizures

Abstract EN

To determine the involvement of oxidative stress in the pathogenesis of acute encephalopathy associated with human herpesvirus-6 (HHV-6) infection, we measured the levels of oxidative stress markers 8-hydroxy-2′-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL), tau protein, and cytokines in cerebrospinal fluid (CSF) obtained from patients with HHV-6-associated acute encephalopathy (HHV-6 encephalopathy) ( n = 16 ) and complex febrile seizures associated with HHV-6 (HHV-6 complex FS) ( n = 10 ) .

We also examined changes in CSF-8OHdG and CSF-HEL levels in patients with HHV-6 encephalopathy before and after treatment with edaravone, a free radical scavenger.

CSF-8-OHdG levels in HHV-6 encephalopathy and HHV-6 complex FS were significantly higher than in control subjects.

In contrast, CSF-HEL levels showed no significant difference between groups.

The levels of total tau protein in HHV-6 encephalopathy were significantly higher than in control subjects.

In six patients with HHV-6 infection (5 encephalopathy and 1 febrile seizure), the CSF-8-OHdG levels of five patients decreased after edaravone treatment.

Our results suggest that oxidative DNA damage is involved in acute encephalopathy associated with HHV-6 infection.