Sphingosine-1-phosphateS1P Receptors Signaling Modulates Cell Migration in Human Bone Marrow-Derived Mesenchymal Stem Cells

Joint Authors

Kong, Yaxian
Wang, Hong
Lin, Tao
Wang, Shuling

Source

Mediators of Inflammation

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-07-23

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases

Abstract EN

The recruitment of bone marrow-derived mesenchymal stem cells (BMSCs) to damaged tissues and sites of inflammation is an essential step for clinical therapy.

However, the signals regulating the motility of these cells are still not fully understood.

Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, is known to have a variety of biological effects on various cells.

Here, we investigated the roles of S1P and S1P receptors (S1PRs) in migration of human BMSCs.

We found that S1P exerted a powerful migratory action on human BMSCs.

Moreover, by employing RNA interference technology and pharmacological tools, we demonstrated that S1PR1 and S1PR3 are responsible for S1P-induced migration of human BMSCs.

In contrast, S1PR2 mediates the inhibition of migration.

Additionally, we explored the downstream signaling pathway of the S1P/S1PRs axis and found that activation of S1PR1 or S1PR3 increased migration of human BMSCs through a Gi/extracellular regulated protein kinases 1/2- (ERK1/2-) dependent pathway, whereas activation of S1PR2 decreased migration through the Rho/Rho-associated protein kinase (ROCK) pathway.

In conclusion, we reveal that the S1P/S1PRs signaling axis regulates the migration of human BMSCs via a dual-directional mechanism.

Thus, selective modulation of S1PR’s activity on human BMSCs may provide an effective approach to immunotherapy or tissue regeneration.

American Psychological Association (APA)

Kong, Yaxian& Wang, Hong& Lin, Tao& Wang, Shuling. 2014. Sphingosine-1-phosphateS1P Receptors Signaling Modulates Cell Migration in Human Bone Marrow-Derived Mesenchymal Stem Cells. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043643

Modern Language Association (MLA)

Kong, Yaxian…[et al.]. Sphingosine-1-phosphateS1P Receptors Signaling Modulates Cell Migration in Human Bone Marrow-Derived Mesenchymal Stem Cells. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043643

American Medical Association (AMA)

Kong, Yaxian& Wang, Hong& Lin, Tao& Wang, Shuling. Sphingosine-1-phosphateS1P Receptors Signaling Modulates Cell Migration in Human Bone Marrow-Derived Mesenchymal Stem Cells. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043643

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1043643