Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro
Joint Authors
Chen, Ying
Tang, Wen
Liu, Fangwei
Song, Laiyu
Dai, Wujing
Li, Chao
Weng, Dong
Chen, Jie
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Silica inhalation can induce chronic lung inflammation and fibrosis.
Upon silica stimulation, activated macrophages trigger the T-lymphocyte which can differentiate into many different types of Th cells, including the recently discovered Th17 cells.
IL-17A, the typical Th17 cytokine, is reported in some inflammatory diseases.
However, the role of IL-17A in silica-induced inflammatory response is still not clear.
The regulatory mechanism of silica-induced Th17 response also needs to be investigated.
So we established a mice primary cell coculture system (macrophage and lymphocyte) to investigate the role of IL-17A in silica-induced inflammatory response in vitro, by using anti-IL-17A mAb and IL-1Ra.
Both anti-IL-17A mAb and IL-1Ra decreased the level of IL-17A and increased the function of Treg cells.
The Th1 response was suppressed and the Th2 response was promoted by the addition of anti-IL-17A mAb or IL-1Ra.
IL-1Ra treatment decreased the level of IL-6, whereas the levels of IL-23 and ROR-γt were increased.
Our study demonstrated that IL-17A reduction altered the pattern of silica-induced Th responses by boosting the function of Treg cells in vitro.
Blocking the function of IL-1 signal pathway could suppress the level of IL-17A, which played the major role in modulating silica-induced Th responses in vitro.
American Psychological Association (APA)
Tang, Wen& Liu, Fangwei& Chen, Ying& Song, Laiyu& Dai, Wujing& Li, Chao…[et al.]. 2014. Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043646
Modern Language Association (MLA)
Tang, Wen…[et al.]. Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043646
American Medical Association (AMA)
Tang, Wen& Liu, Fangwei& Chen, Ying& Song, Laiyu& Dai, Wujing& Li, Chao…[et al.]. Reduction of IL-17A Might Suppress the Th1 Response and Promote the Th2 Response by Boosting the Function of Treg Cells during Silica-Induced Inflammatory Response In Vitro. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043646