Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition
Joint Authors
Rapacz-Leonard, Anna
Dąbrowska, Małgorzata
Janowski, Tomasz
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
During pregnancy in larger mammals, the maternal immune system must tolerate the fetus for months while resisting external infection.
This tolerance is facilitated by immunological communication between the fetus and the mother, which is mediated by Major Histocompatibility Complex I (MHC I) proteins, by leukocytes, and by the cytokines secreted by the leukocytes.
Fetal-maternal immunological communication also supports pregnancy by inducing physiological changes in the mother.
If the mother “misunderstands” the signal sent by the fetus during pregnancy, the fetus will be miscarried or delivered preterm.
Unlike any other maternal organ, the placenta can express paternal antigens.
At parturition, paternal antigens are known to be expressed in cows and may be expressed in horses, possibly so that the maternal immune system will reject the placenta and help to expel it.
This review compares fetal-maternal crosstalk that is mediated by the immune system in three species with pregnancies that last for nine months or longer: humans, cattle, and horses.
It raises the possibility that immunological communication early in pregnancy may prepare the mother for successful expulsion of fetal membranes at parturition.
American Psychological Association (APA)
Rapacz-Leonard, Anna& Dąbrowska, Małgorzata& Janowski, Tomasz. 2014. Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043651
Modern Language Association (MLA)
Rapacz-Leonard, Anna…[et al.]. Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043651
American Medical Association (AMA)
Rapacz-Leonard, Anna& Dąbrowska, Małgorzata& Janowski, Tomasz. Major Histocompatibility Complex I Mediates Immunological Tolerance of the Trophoblast during Pregnancy and May Mediate Rejection during Parturition. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043651
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043651