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Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα
Joint Authors
Streck, Emilio Luiz
Neto, José César Rosa
Teixeira, Alexandre Abílio de Souza
Souza, Camila O.
Batatinha, Helena A. P.
Gomes, Lara M.
Carvalho-Silva, Milena
Mota, Isabella T.
de Lima Júnior, Edson Alves
Hirabara, Sandro Massao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Palmitoleic acid (PMA) has anti-inflammatory and antidiabetic activities.
Here we tested whether these effects of PMA on glucose homeostasis and liver inflammation, in mice fed with high-fat diet (HFD), are PPAR-α dependent.
C57BL6 wild-type (WT) and PPAR-α-knockout (KO) mice fed with a standard diet (SD) or HFD for 12 weeks were treated after the 10th week with oleic acid (OLA, 300 mg/kg of b.w.) or PMA 300 mg/kg of b.w.
Steatosis induced by HFD was associated with liver inflammation only in the KO mice, as shown by the increased hepatic levels of IL1-beta, IL-12, and TNF-α; however, the HFD increased the expression of TLR4 and decreased the expression of IL1-Ra in both genotypes.
Treatment with palmitoleate markedly attenuated the insulin resistance induced by the HFD, increased glucose uptake and incorporation into muscle in vitro, reduced the serum levels of AST in WT mice, decreased the hepatic levels of IL1-beta and IL-12 in KO mice, reduced the expression of TLR-4 and increased the expression of IL-1Ra in WT mice, and reduced the phosphorylation of NF ?B (p65) in the livers of KO mice.
We conclude that palmitoleate attenuates diet-induced insulin resistance, liver inflammation, and damage through mechanisms that do not depend on PPAR-α.
American Psychological Association (APA)
Souza, Camila O.& Teixeira, Alexandre Abílio de Souza& de Lima Júnior, Edson Alves& Batatinha, Helena A. P.& Gomes, Lara M.& Carvalho-Silva, Milena…[et al.]. 2014. Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043653
Modern Language Association (MLA)
Souza, Camila O.…[et al.]. Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043653
American Medical Association (AMA)
Souza, Camila O.& Teixeira, Alexandre Abílio de Souza& de Lima Júnior, Edson Alves& Batatinha, Helena A. P.& Gomes, Lara M.& Carvalho-Silva, Milena…[et al.]. Palmitoleic Acid (N-7) Attenuates the Immunometabolic Disturbances Caused by a High-Fat Diet Independently of PPARα. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043653
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043653