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Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment
Joint Authors
Camara, Niels Olsen Saraiva
Bachert, Claus
Pezato, Rogério
Almeida, Danilo Cândido de
Perez-Novo, Claudina
Gregório, Luís Carlos
Bezerra, Thiago Freire Pinto
Silva, Fernando de Sá
Voegels, Richard Louis
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Nasal polyposis is a severe, chronic inflammatory condition of the paranasal sinuses and is frequently associated with asthma and aspirin sensitivity.
Mesenchymal stem cells exhibit a potent immunosuppressive effect in several inflammatory conditions, and their role in nasal polyposis remains little explored.
Hence, we investigated whether bone marrow-derived mesenchymal stem cells could modulate cell phenotype in the nasal polyp milieu.
After coculture with mesenchymal stem cells, the frequency of these inflammatory cells was found to decrease.
Furthermore, mesenchymal stem cells promoted strong inhibition of CD4+ and CD8+ T cell proliferation, increased the frequency of CD4+CD25+Foxp3 T cells, and changed the global cytokine profile from an inflammatory to an anti-inflammatory response.
We believe that mesenchymal stem cells may be a very useful adjunct for investigation of the inflammatory process in nasal polyposis, contributing to better understanding of the inflammatory course of this condition.
American Psychological Association (APA)
Pezato, Rogério& Almeida, Danilo Cândido de& Bezerra, Thiago Freire Pinto& Silva, Fernando de Sá& Perez-Novo, Claudina& Gregório, Luís Carlos…[et al.]. 2014. Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043654
Modern Language Association (MLA)
Pezato, Rogério…[et al.]. Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043654
American Medical Association (AMA)
Pezato, Rogério& Almeida, Danilo Cândido de& Bezerra, Thiago Freire Pinto& Silva, Fernando de Sá& Perez-Novo, Claudina& Gregório, Luís Carlos…[et al.]. Immunoregulatory Effects of Bone Marrow-Derived Mesenchymal Stem Cells in the Nasal Polyp Microenvironment. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043654