Toll-Like Receptor 2 as a Regulator of Oral Tolerance in the Gastrointestinal Tract
Joint Authors
Tunis, Matthew C.
Marshall, Jean S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Food allergy, other adverse immune responses to foods, inflammatory bowel disease, and eosinophilic esophagitis have become increasingly common in the last 30 years.
It has been proposed in the “hygiene hypothesis” that dysregulated immune responses to environmental microbial stimuli may modify the balance between tolerance and sensitization in some patients.
Of the pattern recognition receptors that respond to microbial signals, toll-like receptors (TLRs) represent the most investigated group.
The relationship between allergy and TLR activation is currently at the frontier of immunology research.
Although TLR2 is abundant in the mucosal environment, little is known about the complex relationship between bystander TLR2 activation by the commensal microflora and the processing of oral antigens.
This review focuses on recent advances in our understanding of the relationship between TLR2 and oral tolerance, with an emphasis on regulatory T cells, eosinophils, B cells, IgA, intestinal regulation, and commensal microbes.
American Psychological Association (APA)
Tunis, Matthew C.& Marshall, Jean S.. 2014. Toll-Like Receptor 2 as a Regulator of Oral Tolerance in the Gastrointestinal Tract. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043676
Modern Language Association (MLA)
Tunis, Matthew C.& Marshall, Jean S.. Toll-Like Receptor 2 as a Regulator of Oral Tolerance in the Gastrointestinal Tract. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043676
American Medical Association (AMA)
Tunis, Matthew C.& Marshall, Jean S.. Toll-Like Receptor 2 as a Regulator of Oral Tolerance in the Gastrointestinal Tract. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043676
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043676