Estrogen Signaling in Metabolic Inflammation
Joint Authors
Monteiro, Rosário
Teixeira, Diana
Calhau, Conceição
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-23
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
There is extensive evidence supporting the interference of inflammatory activation with metabolism.
Obesity, mainly visceral obesity, is associated with a low-grade inflammatory state, triggered by metabolic surplus where specialized metabolic cells such as adipocytes activate cellular stress initiating and sustaining the inflammatory program.
The increasing prevalence of obesity, resulting in increased cardiometabolic risk and precipitating illness such as cardiovascular disease, type 2 diabetes, fatty liver, cirrhosis, and certain types of cancer, constitutes a good example of this association.
The metabolic actions of estrogens have been studied extensively and there is also accumulating evidence that estrogens influence immune processes.
However, the connection between these two fields of estrogen actions has been underacknowledged since little attention has been drawn towards the possible action of estrogens on the modulation of metabolism through their anti-inflammatory properties.
In the present paper, we summarize knowledge on the modification inflammatory processes by estrogens with impact on metabolism and highlight major research questions on the field.
Understanding the regulation of metabolic inflammation by estrogens may provide the basis for the development of therapeutic strategies to the management of metabolic dysfunctions.
American Psychological Association (APA)
Monteiro, Rosário& Teixeira, Diana& Calhau, Conceição. 2014. Estrogen Signaling in Metabolic Inflammation. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-20.
https://search.emarefa.net/detail/BIM-1043681
Modern Language Association (MLA)
Monteiro, Rosário…[et al.]. Estrogen Signaling in Metabolic Inflammation. Mediators of Inflammation No. 2014 (2014), pp.1-20.
https://search.emarefa.net/detail/BIM-1043681
American Medical Association (AMA)
Monteiro, Rosário& Teixeira, Diana& Calhau, Conceição. Estrogen Signaling in Metabolic Inflammation. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-20.
https://search.emarefa.net/detail/BIM-1043681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043681