Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome
Joint Authors
Tang, Ling
Zhao, Ying
Wang, Daoxin
Deng, Wang
Li, Changyi
Li, Qi
Huang, Shicong
Shu, Chang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
To investigate the prognostic significance of endocan, compared with procalcitonin (PCT), C-reactive protein (CRP),white blood cells (WBC), neutrophils (N), and clinical severity scores in patients with ARDS.
Methods.
A total of 42 patients with ARDS were initially enrolled, and there were 20 nonsurvivors and 22 survivors based on hospital mortality.
Plasma levels of biomarkers were measured and the acute physiology and chronic health evaluation II (APACHE II) was calculated on day 1 after the patient met the defining criteria of ARDS.
Results.
Endocan levels significantly correlated with the APACHE II score in the ARDS group (r=0.676, P=0.000, n=42).
Of 42 individuals with ARDS, 20 were dead, and endocan was significantly higher in nonsurvivors than in survivors (median (IQR) 5.01 (2.98–8.44) versus 3.01 (2.36–4.36) ng/mL, P=0.017).
According to the results of the ROC-curve analysis and COX proportional hazards models, endocan can predict mortality of ARDS independently with a hazard ratio of 1.374 (95% CI, 1.150–1.641) and an area of receiver operator characteristic curve (AUROC) of 0.715 (P=0.017).
Moreover, endocan can predict the multiple-organ dysfunction of ARDS.
Conclusion.
Endocan is a promising biomarker to predict the disease severity and mortality in patients with ARDS.
American Psychological Association (APA)
Tang, Ling& Zhao, Ying& Wang, Daoxin& Deng, Wang& Li, Changyi& Li, Qi…[et al.]. 2014. Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043687
Modern Language Association (MLA)
Tang, Ling…[et al.]. Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043687
American Medical Association (AMA)
Tang, Ling& Zhao, Ying& Wang, Daoxin& Deng, Wang& Li, Changyi& Li, Qi…[et al.]. Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043687