Smoking is Associated with Reduced Leptin and Neuropeptide Y Levels and Higher Pain Experience in Patients with Fibromyalgia
Joint Authors
Erlandsson, Malin C.
Bjersing, Jan
Dehlin, Mats
Mannerkorpi, Kaisa
Bokarewa, Maria
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Smoking deregulates neuroendocrine responses to pain supporting production of neuropeptide Y (NpY) by direct stimulation of nicotinic receptors or by inhibiting adipokine leptin.
Present study addressed the effect of cigarette smoking on adipokines and pain parameters, in 62 women with fibromyalgia (FM) pain syndrome with unknown etiology.
Pain was characterized by a visual analogue scale, tender point (TP) counts, pressure pain threshold, and neuroendocrine markers NpY and substance P (sP).
Levels of IGF-1, leptin, resistin, visfatin, and adiponectin were measured in blood and cerebrospinal fluid.
Current smokers (n=18) had lower levels of leptin compared to ex-smokers (n=25, P=0.002), while the expected NpY increase was absent in FM patients.
In smokers, this was transcribed in higher VAS-pain (P=0.04) and TP count (P=0.03), lower pain threshold (P=0.01), since NpY levels were directly related to the pain threshold (rho=0.414) and inversely related to TP counts (rho=-0.375).
This study shows that patients with FM have no increase of NpY levels in response to smoking despite the low levels of leptin.
Deregulation of the balance between leptin and neuropeptide Y may be one of the essential mechanisms of chronic pain in FM.
American Psychological Association (APA)
Bokarewa, Maria& Erlandsson, Malin C.& Bjersing, Jan& Dehlin, Mats& Mannerkorpi, Kaisa. 2014. Smoking is Associated with Reduced Leptin and Neuropeptide Y Levels and Higher Pain Experience in Patients with Fibromyalgia. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043688
Modern Language Association (MLA)
Bokarewa, Maria…[et al.]. Smoking is Associated with Reduced Leptin and Neuropeptide Y Levels and Higher Pain Experience in Patients with Fibromyalgia. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043688
American Medical Association (AMA)
Bokarewa, Maria& Erlandsson, Malin C.& Bjersing, Jan& Dehlin, Mats& Mannerkorpi, Kaisa. Smoking is Associated with Reduced Leptin and Neuropeptide Y Levels and Higher Pain Experience in Patients with Fibromyalgia. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043688