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The Histopathology of Labial Salivary Glands in Primary Sjögren’s Syndrome: Focusing on Follicular Helper T Cells in the Inflammatory Infiltrates
Joint Authors
Zeher, Margit
Papp, Gabor
Szabo, Krisztina
Dezso, Balazs
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Recently, we revealed the importance of follicular helper T cells (TFH) in the pathogenesis of primary Sjögren’s syndrome (pSS).
In the present study, we focused on the site of the inflammation and determined the composition of lymphocyte infiltration in labial salivary gland (LSG) biopsies with special emphasis on TFH and germinal center B cells.
We selected tissue blocks obtained from ten patients at the time of disease onset.
Detection of cell specific markers was performed with immunohistochemical and immunofluorescence stainings.
We evaluated patients’ clinical and laboratory features retrospectively and assessed the relation between disease course and early histopathological findings.
LSG biopsies were graded based on the extension and arrangement level of periductal inflammatory cell infiltrates.
TFH cell markers (CD84, PD-1, and Bcl-6) occurred predominantly in more organized structures with higher focus scores.
The coexpression of CD3 and Bcl-6 markers clearly identified TFH cells close to Bcl-6+ B cells with the typical formation of germinal centers.
Systemic features were developed later in the disease course only in patients with highly structured infiltrates and the presence of TFH cells.
Our observations suggest that the presence of TFH cells in LSGs at the disease onset may predict a more pronounced clinical course of pSS.
American Psychological Association (APA)
Szabo, Krisztina& Papp, Gabor& Dezso, Balazs& Zeher, Margit. 2014. The Histopathology of Labial Salivary Glands in Primary Sjögren’s Syndrome: Focusing on Follicular Helper T Cells in the Inflammatory Infiltrates. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043692
Modern Language Association (MLA)
Szabo, Krisztina…[et al.]. The Histopathology of Labial Salivary Glands in Primary Sjögren’s Syndrome: Focusing on Follicular Helper T Cells in the Inflammatory Infiltrates. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043692
American Medical Association (AMA)
Szabo, Krisztina& Papp, Gabor& Dezso, Balazs& Zeher, Margit. The Histopathology of Labial Salivary Glands in Primary Sjögren’s Syndrome: Focusing on Follicular Helper T Cells in the Inflammatory Infiltrates. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043692
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043692