Effect of the Toll-Like Receptor 4 Antagonist Eritoran on Retinochoroidal Inflammatory Damage in a Rat Model of Endotoxin-Induced Inflammation
Joint Authors
Korkmaz, Safak
Ekici, Feyzahan
Karaca, Emine Esra
Yüksel, Osman
Gülbahar, Özlem
Alper, Murat
Ercan, Sevim
Or, Meral
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
We investigated the effect of eritoran, a Toll-like receptor 4 antagonist, on retinochoroidal inflammatory damage in an endotoxin-induced inflammatory rat model.
Methods.
Endotoxin-induced inflammatory model was obtained by intraperitoneal injection of 1.5 mg/kg lipopolysaccharide (LPS).
Group 1 had control rats; in groups 2-3 LPS and 0.5 mg/kg sterile saline were injected; and in groups 4-5 LPS and 0.5 mg/kg eritoran were injected.
Blood samples were taken and eyes were enucleated after 12 hours (h) (groups 2 and 4) or 24 hours (Groups 3 and 5).
Tumor necrosis factor-α (TNF-α) and malondialdehyde (MDA) levels in the serum and retinochoroidal tissue and nuclear factor kappa-B (NFκB) levels in retinochoroidal tissue were determined.
Histopathological examination was performed and retinochoroidal changes were scored.
Results.
Eritoran treatment resulted in lower levels of TNF-α, MDA, and NFκB after 12 h which became significant after 24 h.
Serum TNF-α and retinochoroidal tissue NFκB levels were similar to control animals at the 24th h of the study.
Eritoran significantly reversed histopathological damage after 24 h.
Conclusions.
Eritoran treatment resulted in less inflammatory damage in terms of serum and retinochoroidal tissue parameters.
American Psychological Association (APA)
Ekici, Feyzahan& Karaca, Emine Esra& Korkmaz, Safak& Yüksel, Osman& Gülbahar, Özlem& Alper, Murat…[et al.]. 2014. Effect of the Toll-Like Receptor 4 Antagonist Eritoran on Retinochoroidal Inflammatory Damage in a Rat Model of Endotoxin-Induced Inflammation. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043699
Modern Language Association (MLA)
Ekici, Feyzahan…[et al.]. Effect of the Toll-Like Receptor 4 Antagonist Eritoran on Retinochoroidal Inflammatory Damage in a Rat Model of Endotoxin-Induced Inflammation. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043699
American Medical Association (AMA)
Ekici, Feyzahan& Karaca, Emine Esra& Korkmaz, Safak& Yüksel, Osman& Gülbahar, Özlem& Alper, Murat…[et al.]. Effect of the Toll-Like Receptor 4 Antagonist Eritoran on Retinochoroidal Inflammatory Damage in a Rat Model of Endotoxin-Induced Inflammation. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043699