Paeonol Attenuates Cigarette Smoke-Induced Lung Inflammation by Inhibiting ROS-Sensitive Inflammatory Signaling
Joint Authors
Liu, Meng-Han
Lin, An-Hsuan
Lee, Hung-Fu
Ko, Hsin-Kuo
Kou, Yu Ru
Lee, Tzong-Shyuan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cigarette smoking causes persistent lung inflammation that is mainly regulated by redox-sensitive pathways.
We have previously reported that cigarette smoke (CS) activates reactive oxygen species- (ROS-) sensitive mitogen-activated protein kinases (MAPKs)/nuclear factor-κB (NF-κB) signaling leading to induction of lung inflammation.
Paeonol, the main phenolic compound present in the Chinese herb Paeonia suffruticosa, has antioxidant and anti-inflammatory properties.
However, whether paeonol has similar beneficial effects against CS-induced lung inflammation remains unclear.
Using a murine model, we showed that chronic CS exposure for 4 weeks caused pulmonary inflammatory infiltration, increased lung vascular permeability, elevated lung levels of chemokines, cytokines, and 4-hydroxynonenal (an oxidative stress biomarker), and induced lung inflammation; all of these CS-induced events were suppressed by chronic treatment with paeonol.
Using human bronchial epithelial cells (HBECs), we demonstrated that cigarette smoke extract (CSE) sequentially increased extracellular and intracellular levels of ROS, activated the MAPKs/NF-κB signaling, and induced interleukin-8 (IL-8); all these CSE-induced events were inhibited by paeonol pretreatment.
Our findings suggest a novel role for paeonol in alleviating the oxidative stress and lung inflammation induced by chronic CS exposure in vivo and in suppressing CSE-induced IL-8 in vitro via its antioxidant function and an inhibition of the MAPKs/NF-κB signaling.
American Psychological Association (APA)
Liu, Meng-Han& Lin, An-Hsuan& Lee, Hung-Fu& Ko, Hsin-Kuo& Lee, Tzong-Shyuan& Kou, Yu Ru. 2014. Paeonol Attenuates Cigarette Smoke-Induced Lung Inflammation by Inhibiting ROS-Sensitive Inflammatory Signaling. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043702
Modern Language Association (MLA)
Liu, Meng-Han…[et al.]. Paeonol Attenuates Cigarette Smoke-Induced Lung Inflammation by Inhibiting ROS-Sensitive Inflammatory Signaling. Mediators of Inflammation No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043702
American Medical Association (AMA)
Liu, Meng-Han& Lin, An-Hsuan& Lee, Hung-Fu& Ko, Hsin-Kuo& Lee, Tzong-Shyuan& Kou, Yu Ru. Paeonol Attenuates Cigarette Smoke-Induced Lung Inflammation by Inhibiting ROS-Sensitive Inflammatory Signaling. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043702