21-O-Angeloyltheasapogenol E3, a Novel Triterpenoid Saponin from the Seeds of Tea Plants, Inhibits Macrophage-Mediated Inflammatory Responses in a NF-κB-Dependent Manner
Joint Authors
Yang, Woo Seok
Shin, Song Seok
Kim, Ji Hye
Kim, Han Gyung
Kim, Eunji
Yang, Sungjae
Ko, Jaeyoung
Sung, Nak Yoon
Rho, Ho Sik
Hong, Yong Deog
Cho, Jae Youl
Park, Jae Gwang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
21-O-Angeloyltheasapogenol E3 (ATS-E3) is a triterpenoid saponin recently isolated from the seeds of the tea tree Camellia sinensis (L.) O.
Kuntze.
ATS-E3 has several beneficial properties including anti-inflammatory, antidiabetic, antiatherosclerotic, and anticancer effects.
Unlike other phenolic compounds isolated from tea plants, there are no studies reporting the pharmacological action of ATS-E3.
In this study, we therefore aimed to explore the cellular and molecular inhibitory activities of ATS-E3 in macrophage-mediated inflammatory responses.
ATS-E3 remarkably diminished cellular responses of macrophages such as FITC-dextran-induced phagocytic uptake, sodium nitroprusside- (SNP-) induced radical generation, and LPS-induced nitric oxide (NO) production.
Analysis of its molecular activity showed that this compound significantly suppressed the expression of inducible NO synthase (iNOS), nuclear translocation of nuclear factor- (NF-) κB subunits (p50 and p65), phosphorylation of inhibitor of κB kinase (IKK), and the enzyme activity of AKT1.
Taken together, the novel triterpenoid saponin compound ATS-E3 contributes to the beneficial effects of tea plants by exerting anti-inflammatory and antioxidative activities in an AKT/IKK/NF-κB-dependent manner.
American Psychological Association (APA)
Yang, Woo Seok& Ko, Jaeyoung& Kim, Eunji& Kim, Ji Hye& Park, Jae Gwang& Sung, Nak Yoon…[et al.]. 2014. 21-O-Angeloyltheasapogenol E3, a Novel Triterpenoid Saponin from the Seeds of Tea Plants, Inhibits Macrophage-Mediated Inflammatory Responses in a NF-κB-Dependent Manner. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043703
Modern Language Association (MLA)
Yang, Woo Seok…[et al.]. 21-O-Angeloyltheasapogenol E3, a Novel Triterpenoid Saponin from the Seeds of Tea Plants, Inhibits Macrophage-Mediated Inflammatory Responses in a NF-κB-Dependent Manner. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043703
American Medical Association (AMA)
Yang, Woo Seok& Ko, Jaeyoung& Kim, Eunji& Kim, Ji Hye& Park, Jae Gwang& Sung, Nak Yoon…[et al.]. 21-O-Angeloyltheasapogenol E3, a Novel Triterpenoid Saponin from the Seeds of Tea Plants, Inhibits Macrophage-Mediated Inflammatory Responses in a NF-κB-Dependent Manner. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043703