Chemokines and Chemokine Receptors in Multiple Sclerosis
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration.
The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development of this disease.
Chemokines, which are small peptide mediators, can attract pathogenic cells to the sites of inflammation.
Each helper T cell subset expresses different chemokine receptors so as to exert their different functions in the pathogenesis of MS.
Recently published results have shown that the levels of some chemokines and chemokine receptors are increased in blood and cerebrospinal fluid of MS patients.
This review describes the advanced researches on the role of chemokines and chemokine receptors in the development of MS and discusses the potential therapy of this disease targeting the chemokine network.
American Psychological Association (APA)
Cheng, Wenjing& Chen, Guangjie. 2014. Chemokines and Chemokine Receptors in Multiple Sclerosis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043704
Modern Language Association (MLA)
Cheng, Wenjing& Chen, Guangjie. Chemokines and Chemokine Receptors in Multiple Sclerosis. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043704
American Medical Association (AMA)
Cheng, Wenjing& Chen, Guangjie. Chemokines and Chemokine Receptors in Multiple Sclerosis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043704