Rotenone Remarkably Attenuates Oxidative Stress, Inflammation, and Fibrosis in Chronic Obstructive Uropathy
Joint Authors
Sun, Ying
Ding, Guixia
Zhang, Yue
Zhao, Daqiang
Jia, Zhanjun
Huang, Songming
Zhang, Aihua
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mitochondrial abnormality has been shown in many kidney disease models.
However, its role in the pathogenesis of chronic kidney diseases (CKDs) is still uncertain.
In present study, a mitochondrial complex I inhibitor rotenone was applied to the mice subjected to unilateral ureteral obstruction (UUO).
Following 7-days rotenone treatment, a remarkable attenuation of tubular injury was detected by PAS staining.
In line with the improvement of kidney morphology, rotenone remarkably blunted fibrotic response as shown by downregulation of fibronectin (FN), plasminogen activator inhibitor-1 (PAI-1), collagen I, collagen III, and α-SMA, paralleled with a substantial decrease of TGF-β 1.
Meanwhile, the oxidative stress markers thiobarbituric acid-reactive substances (TBARS) and heme oxygenase 1 (HO-1) and inflammatory markers TNF-α, IL-1β, and ICAM-1 were markedly decreased.
More importantly, the reduction of mitochondrial DNA copy number and mitochondrial NADH dehydrogenase subunit 1 (mtND1) expression in obstructed kidneys was moderately but significantly restored by rotenone, suggesting an amelioration of mitochondrial injury.
Collectively, mitochondrial complex I inhibitor rotenone protected kidneys against obstructive injury possibly via inhibition of mitochondrial oxidative stress, inflammation, and fibrosis, suggesting an important role of mitochondrial dysfunction in the pathogenesis of obstructive kidney disease.
American Psychological Association (APA)
Sun, Ying& Zhang, Yue& Zhao, Daqiang& Ding, Guixia& Huang, Songming& Zhang, Aihua…[et al.]. 2014. Rotenone Remarkably Attenuates Oxidative Stress, Inflammation, and Fibrosis in Chronic Obstructive Uropathy. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043705
Modern Language Association (MLA)
Sun, Ying…[et al.]. Rotenone Remarkably Attenuates Oxidative Stress, Inflammation, and Fibrosis in Chronic Obstructive Uropathy. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043705
American Medical Association (AMA)
Sun, Ying& Zhang, Yue& Zhao, Daqiang& Ding, Guixia& Huang, Songming& Zhang, Aihua…[et al.]. Rotenone Remarkably Attenuates Oxidative Stress, Inflammation, and Fibrosis in Chronic Obstructive Uropathy. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043705
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043705