Angiogenesis-Related Biomarkers in Patients with Alcoholic Liver Disease: Their Association with Liver Disease Complications and Outcome
Joint Authors
Rolinski, Jacek
Cichoz-Lach, Halina
Madro, Agnieszka
Szczerbinski, Mariusz
Kasztelan-Szczerbinska, Beata
Celinski, Krzysztof
Slomka, Maria
Surdacka, Agata
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Angiogenesis is believed to be implicated in the pathogenesis of alcoholic liver disease (ALD).
We aimed to explore the usefulness and accuracy of plasma angiogenic biomarkers for noninvasive evaluation of the severity of liver failure and ALD outcome.
One hundred and forty-seven patients with ALD were prospectively enrolled and assessed based on their (1) gender, (2) age, (3) severity of liver dysfunction according to the Child-Turcotte-Pugh and MELD scores, and (4) the presence of ALD complications.
Plasma levels of vascular endothelial growth factor (VEGF-A) and angiopoietins 1 and 2 (Ang1 and Ang2) were investigated using ELISAs.
Multivariable logistic regression was applied in order to select independent predictors of advanced liver dysfunction and the disease complications.
Significantly higher concentrations of Ang2 and VEGF-A in ALD patients as compared to controls were found.
There was no difference in Ang1 levels in both groups.
A positive correlation of Ang2 levels with INR (Rho 0.66; P<0.0001) and its inverse correlation with plasma albumin levels (Rho –0.62; P<0.0001) were found.
High Ang2 concentrations turned out to be an independent predictor of severe liver dysfunction, as well as hepatic encephalopathy and renal impairment.
Ang2 possessed the highest diagnostic and prognostic potential among three studied angiogenesis-related molecules.
American Psychological Association (APA)
Kasztelan-Szczerbinska, Beata& Surdacka, Agata& Slomka, Maria& Rolinski, Jacek& Celinski, Krzysztof& Cichoz-Lach, Halina…[et al.]. 2014. Angiogenesis-Related Biomarkers in Patients with Alcoholic Liver Disease: Their Association with Liver Disease Complications and Outcome. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043708
Modern Language Association (MLA)
Kasztelan-Szczerbinska, Beata…[et al.]. Angiogenesis-Related Biomarkers in Patients with Alcoholic Liver Disease: Their Association with Liver Disease Complications and Outcome. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043708
American Medical Association (AMA)
Kasztelan-Szczerbinska, Beata& Surdacka, Agata& Slomka, Maria& Rolinski, Jacek& Celinski, Krzysztof& Cichoz-Lach, Halina…[et al.]. Angiogenesis-Related Biomarkers in Patients with Alcoholic Liver Disease: Their Association with Liver Disease Complications and Outcome. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043708
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043708