Inflammatory Modulation Effect of Glycopeptide from Ganoderma capense (Lloyd) Teng
Joint Authors
Yao, Wenbing
Zhou, Yan
Chen, Song
Ding, Ran
Gao, Xiangdong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Glycopeptide from Ganoderma capense (Lloyd) Teng (GCGP) injection is widely used in kinds of immune disorders, but little is known about the molecular mechanisms of how GCGP could interfere with immune cell function.
In the present study, we have found that GCGP had inflammatory modulation effects on macrophage cells to maintain NO production and iNOS expression at the normal level.
Furthermore, western blot analysis showed that the underlying mechanism of immunomodulatory effect of GCGP involved NF-κB p65 translation, IκB phosphorylation, and degradation; NF-κB inhibitor assays also confirmed the results.
In addition, competition study showed that GCGP could inhibit LPS from binding to macrophage cells.
Our data indicates that GCGP, which may share the same receptor(s) expressed by macrophage cells with LPS, exerted immunomodulatory effect in a NF-κB-dependent signaling pathway in macrophages.
American Psychological Association (APA)
Zhou, Yan& Chen, Song& Ding, Ran& Yao, Wenbing& Gao, Xiangdong. 2014. Inflammatory Modulation Effect of Glycopeptide from Ganoderma capense (Lloyd) Teng. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043720
Modern Language Association (MLA)
Zhou, Yan…[et al.]. Inflammatory Modulation Effect of Glycopeptide from Ganoderma capense (Lloyd) Teng. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043720
American Medical Association (AMA)
Zhou, Yan& Chen, Song& Ding, Ran& Yao, Wenbing& Gao, Xiangdong. Inflammatory Modulation Effect of Glycopeptide from Ganoderma capense (Lloyd) Teng. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043720