Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions
Joint Authors
Kolářová, Hana
Ambrůzová, Barbora
Švihálková Šindlerová, Lenka
Klinke, Anna
Kubala, Lukas
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The glycocalyx of the endothelium is an intravascular compartment that creates a barrier between circulating blood and the vessel wall.
The glycocalyx is suggested to play an important role in numerous physiological processes including the regulation of vascular permeability, the prevention of the margination of blood cells to the vessel wall, and the transmission of shear stress.
Various theoretical models and experimental approaches provide data about changes to the structure and functions of the glycocalyx under various types of inflammatory conditions.
These alterations are suggested to promote inflammatory processes in vessels and contribute to the pathogenesis of number of diseases.
In this review we summarize current knowledge about the modulation of the glycocalyx under inflammatory conditions and the consequences for the course of inflammation in vessels.
The structure and functions of endothelial glycocalyx are briefly discussed in the context of methodological approaches regarding the determination of endothelial glycocalyx and the uncertainty and challenges involved in glycocalyx structure determination.
In addition, the modulation of glycocalyx structure under inflammatory conditions and the possible consequences for pathogenesis of selected diseases and medical conditions (in particular, diabetes, atherosclerosis, ischemia/reperfusion, and sepsis) are summarized.
Finally, therapeutic strategies to ameliorate glycocalyx dysfunction suggested by various authors are discussed.
American Psychological Association (APA)
Kolářová, Hana& Ambrůzová, Barbora& Švihálková Šindlerová, Lenka& Klinke, Anna& Kubala, Lukas. 2014. Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1043729
Modern Language Association (MLA)
Kolářová, Hana…[et al.]. Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions. Mediators of Inflammation No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1043729
American Medical Association (AMA)
Kolářová, Hana& Ambrůzová, Barbora& Švihálková Šindlerová, Lenka& Klinke, Anna& Kubala, Lukas. Modulation of Endothelial Glycocalyx Structure under Inflammatory Conditions. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1043729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043729