Hantaan Virus Infection Induces CXCL10 Expression through TLR3, RIG-I, and MDA-5 Pathways Correlated with the Disease Severity

Joint Authors

Zhang, Yun
Jin, Boquan
Wang, Jiuping
Zhuang, Ran
Zhang, Yusi
Ma, Ying
Yang, Kun
Yang, Angang
Xu, Zhuwei
Zhang, Chunmei
Liu, Bei
Yi, Jing

Source

Mediators of Inflammation

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-02-22

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases

Abstract EN

Hantaan virus (HTNV) is a major agent causing hemorrhagic fever with renal syndrome (HFRS).

Although the pathogenesis of HFRS is unclear, some reports have suggested that the abundant production of proinflammatory cytokines and uncontrolled inflammatory responses may contribute to the development of HFRS.

CXCL10 is one of these cytokines and is found to be involved in the pathogenesis of many virus infectious diseases.

However, the role of CXCL10 in the pathogenesis of HFRS and the molecular regulation mechanism of CXCL10 in HTNV infection remain unknown.

In this study, we report that CXCL10 expresses highly in the HFRS patients’ sera and the elevated CXCL10 is positively correlated with the severity of HFRS.

We find that HTNV, a single-strand RNA virus, can act as a double-strand RNA to activate the TLR3, RIG-I, and MDA-5 signaling pathways.

Through the downstream transcription factors of these pathways, NF-κB and IRF7, which bind directly to the CXCL10’s promoter, the expression of CXCL10 is increased.

Our results may help to better understand the role of CXCL10 in the development of HFRS and may provide some novel insights into the immune response of HTNV infection.

American Psychological Association (APA)

Zhang, Yusi& Liu, Bei& Ma, Ying& Yi, Jing& Zhang, Chunmei& Zhang, Yun…[et al.]. 2014. Hantaan Virus Infection Induces CXCL10 Expression through TLR3, RIG-I, and MDA-5 Pathways Correlated with the Disease Severity. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043737

Modern Language Association (MLA)

Zhang, Yusi…[et al.]. Hantaan Virus Infection Induces CXCL10 Expression through TLR3, RIG-I, and MDA-5 Pathways Correlated with the Disease Severity. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043737

American Medical Association (AMA)

Zhang, Yusi& Liu, Bei& Ma, Ying& Yi, Jing& Zhang, Chunmei& Zhang, Yun…[et al.]. Hantaan Virus Infection Induces CXCL10 Expression through TLR3, RIG-I, and MDA-5 Pathways Correlated with the Disease Severity. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043737

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1043737