Overexpression and Selectively Regulatory Roles of IL-23IL-17 Axis in the Lesions of Oral Lichen Planus
Joint Authors
Lu, Rui
Zeng, Xin
Han, Qi
Lin, Mu
Long, Long
Dan, Hongxia
Zhou, Gang
Chen, Qian-ming
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Interleukin- (IL-) 23/IL-17 axis is a newly discovered proinflammatory signaling pathway and has been implicated in the pathogenesis of many chronic inflammatory and immune disorders.
Here we investigated whether the IL-23/IL-17 axis was present and functional in the lesions of oral lichen planus (OLP), a chronic inflammatory disease affecting the oral mucosa.
Using immunohistochemistry and quantitative PCR, we found that the subunits of IL-23 and IL-17 were overexpressed in OLP lesions than in normal oral mucosa tissues.
In addition, the expressions of IL-23 and IL-17 are positively correlated in reticular OLP tissues.
Results from in vitro studies revealed that exogenous IL-23 could increase the percentage of Th17 cells and IL-17 production in the CD4+T cells from reticular OLP patients.
Furthermore, we also found that exogenous IL-17 could significantly enhance the mRNA expressions of β-defensin-2, -3, CCL-20, IL-8, and TNF-α, but not β-defensin-1, CXCL-9, -10, -11, CCL-5, and IL-6 in human oral keratinocytes.
Taken together, our results revealed an overexpression pattern and selectively regulatory roles of IL-23/IL-17 axis in the OLP lesions, suggesting that it may be a pivotal regulatory pathway in the complex immune network of OLP lesions.
American Psychological Association (APA)
Lu, Rui& Zeng, Xin& Han, Qi& Lin, Mu& Long, Long& Dan, Hongxia…[et al.]. 2014. Overexpression and Selectively Regulatory Roles of IL-23IL-17 Axis in the Lesions of Oral Lichen Planus. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043739
Modern Language Association (MLA)
Lu, Rui…[et al.]. Overexpression and Selectively Regulatory Roles of IL-23IL-17 Axis in the Lesions of Oral Lichen Planus. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043739
American Medical Association (AMA)
Lu, Rui& Zeng, Xin& Han, Qi& Lin, Mu& Long, Long& Dan, Hongxia…[et al.]. Overexpression and Selectively Regulatory Roles of IL-23IL-17 Axis in the Lesions of Oral Lichen Planus. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043739