Monocyte Subsets in Schistosomiasis Patients with Periportal Fibrosis
Joint Authors
De Souza, Robson Da Paixão
Lopes, Diego Mota
Cardoso, Luciana Santos
Fernandes, Jamille Souza
Carvalho, Edgar M.
Araujo, Maria Ilma
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A major issue with Schistosoma mansoni infection is the development of periportal fibrosis, which is predominantly caused by the host immune response to egg antigens.
Experimental studies have pointed to the participation of monocytes in the pathogenesis of liver fibrosis.
The aim of this study was to characterize the subsets of monocytes in individuals with different degrees of periportal fibrosis secondary to schistosomiasis.
Monocytes were classified into classical (CD14++CD16−), intermediate (CD14++CD16+), and nonclassical (CD14+CD16++).
The expressions of monocyte markers and cytokines were assessed using flow cytometry.
The frequency of classical monocytes was higher than the other subsets.
The expression of HLA-DR, IL-6, TNF-α, and TGF-β was higher in monocytes from individuals with moderate to severe fibrosis as compared to other groups.
Although no differences were observed in receptors expression (IL-4R and IL-10R) between groups of patients, the expression of IL-12 was lower in monocytes from individuals with moderate to severe fibrosis, suggesting a protective role of this cytokine in the development of fibrosis.
Our data support the hypothesis that the three different monocyte populations participate in the immunopathogenesis of periportal fibrosis, since they express high levels of proinflammatory and profibrotic cytokines and low levels of regulatory markers.
American Psychological Association (APA)
Fernandes, Jamille Souza& Araujo, Maria Ilma& Lopes, Diego Mota& De Souza, Robson Da Paixão& Carvalho, Edgar M.& Cardoso, Luciana Santos. 2014. Monocyte Subsets in Schistosomiasis Patients with Periportal Fibrosis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043743
Modern Language Association (MLA)
Fernandes, Jamille Souza…[et al.]. Monocyte Subsets in Schistosomiasis Patients with Periportal Fibrosis. Mediators of Inflammation No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1043743
American Medical Association (AMA)
Fernandes, Jamille Souza& Araujo, Maria Ilma& Lopes, Diego Mota& De Souza, Robson Da Paixão& Carvalho, Edgar M.& Cardoso, Luciana Santos. Monocyte Subsets in Schistosomiasis Patients with Periportal Fibrosis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1043743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043743