Golimumab as Rescue Therapy for Refractory Immune-Mediated Uveitis: A Three-Center Experience
Joint Authors
Gonzalez-Gay, Miguel A.
Calvo-Río, Vanesa
Adán, Alfredo
Blanco, Ricardo
Álvarez-Castro, Carolina
Mesquida, Marina
Calleja, Sara
Ruíz de Morales, José G.
Cordero-Coma, Miguel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
To evaluate, in three Spanish tertiary referral centres, the short-term safety and efficacy of golimumab (GLM) for treatment of immune-mediated uveitis resistant to previous immunosuppressive therapy.
Methods.
Nonrandomized retrospective interventional case series.
Thirteen patients with different types of uveitis that were resistant to treatment with at least 2 previous immunosuppressors were included in this study.
All included patients were treated with GLM (50 mg every four weeks) during at least 6 months.
Clinical evaluation and treatment-related side effects were assessed at least four times in all included patients.
Results.
Eight men and 5 women (22 affected eyes) with a median age of 30 years (range 20–38) and active immune-mediated uveitides were studied.
GLM was used in combination with conventional immunosuppressors in 7 patients (53.8%).
GLM therapy achieved complete control of inflammation in 12/13 patients (92.3%) after six months of treatment.
There was a statistically significant improvement in mean BCVA (0.60 versus 0.68, P = 0.009 ) and mean 1 mm central retinal thickness (317 versus 261.2 μ, P = 0.05 ) at the six-month endpoint when compared to basal values.
No major systemic adverse effects associated with GLM therapy were observed.
Conclusions.
GLM is a new and promising therapeutic option for patients with severe and refractory uveitis.
American Psychological Association (APA)
Cordero-Coma, Miguel& Calvo-Río, Vanesa& Adán, Alfredo& Blanco, Ricardo& Álvarez-Castro, Carolina& Mesquida, Marina…[et al.]. 2014. Golimumab as Rescue Therapy for Refractory Immune-Mediated Uveitis: A Three-Center Experience. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043751
Modern Language Association (MLA)
Cordero-Coma, Miguel…[et al.]. Golimumab as Rescue Therapy for Refractory Immune-Mediated Uveitis: A Three-Center Experience. Mediators of Inflammation No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1043751
American Medical Association (AMA)
Cordero-Coma, Miguel& Calvo-Río, Vanesa& Adán, Alfredo& Blanco, Ricardo& Álvarez-Castro, Carolina& Mesquida, Marina…[et al.]. Golimumab as Rescue Therapy for Refractory Immune-Mediated Uveitis: A Three-Center Experience. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043751