Circulating Th17, Th22, and Th1 Cells Are Elevated in the Guillain-Barré Syndrome and Downregulated by IVIg Treatments
Joint Authors
Zhang, Hong-Liang
Zhu, Jie
Concha, Hernan
Li, Shujuan
Jin, Tao
Yu, Hong
Meng, Fanhua
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The Guillain-Barré syndrome (GBS) is considered a T helper 1 (Th1) cells-mediated acute inflammatory peripheral neuropathy.
However, some changes in GBS could not be explained completely by Th1 cells pathogenic role.
Recently, Th17 cells have been identified and can mediate tissue inflammation and autoimmune response.
Therefore, a study on the role of Th17 and Th22 cells and their cytokines in GBS is necessary for exploring the pathogenesis of GBS.
Here, we detected the frequency of Th1, Th17, and Th22 cells by using 4-color flow cytometry and we detected the plasma levels of IL-17 and IL-22 by ELISA in GBS patients, relapsing-remitting multiple sclerosis patients at the acute phase of relapse, viral encephalitis or meningitis patients and healthy controls.
Our data showed that the frequency of circulating Th1, Th17, and Th22 cells was significantly increased in GBS patients.
The plasma levels of IL-17 and IL-22 in GBS and relapsing-remitting multiple sclerosis at the acute phase of relapse were also markedly elevated.
Enhanced circulating Th22 cells were correlated with GBS severity.
Intravenous immunoglobulin therapy downregulated Th17, and Th22 cells and the plasma levels of IL-17 and IL-22 in GBS patients.
Th17 and Th22 cells may be involved in the pathogenesis of GBS, and intravenous immunoglobulin mediates therapeutic effects by downregulating these cells and their cytokines.
American Psychological Association (APA)
Li, Shujuan& Jin, Tao& Zhang, Hong-Liang& Yu, Hong& Meng, Fanhua& Concha, Hernan…[et al.]. 2014. Circulating Th17, Th22, and Th1 Cells Are Elevated in the Guillain-Barré Syndrome and Downregulated by IVIg Treatments. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043771
Modern Language Association (MLA)
Li, Shujuan…[et al.]. Circulating Th17, Th22, and Th1 Cells Are Elevated in the Guillain-Barré Syndrome and Downregulated by IVIg Treatments. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043771
American Medical Association (AMA)
Li, Shujuan& Jin, Tao& Zhang, Hong-Liang& Yu, Hong& Meng, Fanhua& Concha, Hernan…[et al.]. Circulating Th17, Th22, and Th1 Cells Are Elevated in the Guillain-Barré Syndrome and Downregulated by IVIg Treatments. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043771