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Impact of STATSOCS mRNA Expression Levels after Major Injury
Joint Authors
Brumann, M.
Kusmenkov, T.
Biberthaler, P.
Mutschler, W.
Bogner, V.
Matz, M.
Stegmaier, J.
Kanz, K.-G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Fulminant changes in cytokine receptor signalling might provoke severe pathological alterations after multiple trauma.
The aim of this study was to evaluate the posttraumatic imbalance of the innate immune system with a special focus on the STAT/SOCS family.
Methods.
20 polytraumatized patients were included.
Blood samples were drawn 0 h–72 h after trauma; mRNA expression profiles of IL-10, STAT 3, SOCS 1, and SOCS 3 were quantified by qPCR.
Results.
IL-10 mRNA expression increased significantly in the early posttraumatic period.
STAT 3 mRNA expressions showed a significant maximum at 6 h after trauma.
SOCS 1 levels significantly decreased 6 h–72 h after trauma.
SOCS 3 levels were significantly higher in nonsurvivors 6 h after trauma.
Conclusion.
We present a serial, sequential investigation in human neutrophil granulocytes of major trauma patients evaluating mRNA expression profiles of IL-10, STAT 3, SOCS 1, and SOCS 3.
Posttraumatically, immune disorder was accompanied by a significant increase of IL-10 and STAT 3 mRNA expression, whereas SOCS 1 mRNA levels decreased after injury.
We could demonstrate that death after trauma was associated with higher SOCS 3 mRNA levels already at 6 h after trauma.
To support our results, further investigations have to evaluate protein levels of STAT/SOCS family in terms of posttraumatic immune imbalance.
American Psychological Association (APA)
Brumann, M.& Matz, M.& Kusmenkov, T.& Stegmaier, J.& Biberthaler, P.& Kanz, K.-G.…[et al.]. 2014. Impact of STATSOCS mRNA Expression Levels after Major Injury. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043788
Modern Language Association (MLA)
Brumann, M.…[et al.]. Impact of STATSOCS mRNA Expression Levels after Major Injury. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043788
American Medical Association (AMA)
Brumann, M.& Matz, M.& Kusmenkov, T.& Stegmaier, J.& Biberthaler, P.& Kanz, K.-G.…[et al.]. Impact of STATSOCS mRNA Expression Levels after Major Injury. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043788
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043788