Role of Cytokines and Toll-Like Receptors in the Immunopathogenesis of Guillain-Barré Syndrome
Joint Authors
Nyati, Kishan Kumar
Prasad, Kashi Nath
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Guillain-Barré syndrome (GBS) is an autoimmune disease of the peripheral nervous system, mostly triggered by an aberrant immune response to an infectious pathogen.
Although several infections have been implicated in the pathogenesis of GBS, not all such infected individuals develop this disease.
Moreover, infection with a single agent might also lead to different subtypes of GBS emphasizing the role of host factors in the development of GBS.
The host factors regulate a broad range of inflammatory processes that are involved in the pathogenesis of autoimmune diseases including GBS.
Evidences suggest that systemically and locally released cytokines and their involvement in immune-mediated demyelination and axonal damage of peripheral nerves are important in the pathogenesis of GBS.
Toll-like receptors (TLRs) link innate and adaptive immunity through transcription of several proinflammatory cytokines.
TLR genes may increase susceptibility to microbial infections; an attenuated immune response towards antigen and downregulation of cytokines occurs due to mutation in the gene.
Herein, we discuss the crucial role of host factors such as cytokines and TLRs that activate the immune response and are involved in the pathogenesis of the disease.
American Psychological Association (APA)
Nyati, Kishan Kumar& Prasad, Kashi Nath. 2014. Role of Cytokines and Toll-Like Receptors in the Immunopathogenesis of Guillain-Barré Syndrome. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043796
Modern Language Association (MLA)
Nyati, Kishan Kumar& Prasad, Kashi Nath. Role of Cytokines and Toll-Like Receptors in the Immunopathogenesis of Guillain-Barré Syndrome. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043796
American Medical Association (AMA)
Nyati, Kishan Kumar& Prasad, Kashi Nath. Role of Cytokines and Toll-Like Receptors in the Immunopathogenesis of Guillain-Barré Syndrome. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043796