Potent Anti-Inflammatory Activity of Pyrenocine A Isolated from the Marine-Derived Fungus Penicillium paxilli Ma(G)K
Joint Authors
Toledo, Thaís Regina
Dejani, Naiara N.
Monnazzi, Luis Gustavo Silva
Kossuga, Miriam H.
Berlinck, Roberto G. S.
Sette, Lara D.
Medeiros, Alexandra I.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Very little is known about the immunomodulatory potential of secondary metabolites isolated from marine microorganisms.
In the present study, we characterized pyrenocine A, which is produced by the marine-derived fungus Penicillium paxilli Ma(G)K and possesses anti-inflammatory activity.
Pyrenocine A was able to suppress, both pretreatment and posttreatment, the LPS-induced activation of macrophages via the inhibition of nitrite production and the synthesis of inflammatory cytokines and PGE2.
Pyrenocine A also exhibited anti-inflammatory effects on the expression of receptors directly related to cell migration (Mac-1) as well as costimulatory molecules involved in lymphocyte activation (B7.1).
Nitrite production was inhibited by pyrenocine A in macrophages stimulated with CpG but not Poly I:C, suggesting that pyrenocine A acts through the MyD88-dependent intracellular signaling pathway.
Moreover, pyrenocine A is also able to inhibit the expression of genes related to NFκB-mediated signal transduction on macrophages stimulated by LPS.
Our results indicate that pyrenocine A has promissory anti-inflammatory properties and additional experiments are necessary to confirm this finding in vivo model.
American Psychological Association (APA)
Toledo, Thaís Regina& Dejani, Naiara N.& Monnazzi, Luis Gustavo Silva& Kossuga, Miriam H.& Berlinck, Roberto G. S.& Sette, Lara D.…[et al.]. 2014. Potent Anti-Inflammatory Activity of Pyrenocine A Isolated from the Marine-Derived Fungus Penicillium paxilli Ma(G)K. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043799
Modern Language Association (MLA)
Toledo, Thaís Regina…[et al.]. Potent Anti-Inflammatory Activity of Pyrenocine A Isolated from the Marine-Derived Fungus Penicillium paxilli Ma(G)K. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043799
American Medical Association (AMA)
Toledo, Thaís Regina& Dejani, Naiara N.& Monnazzi, Luis Gustavo Silva& Kossuga, Miriam H.& Berlinck, Roberto G. S.& Sette, Lara D.…[et al.]. Potent Anti-Inflammatory Activity of Pyrenocine A Isolated from the Marine-Derived Fungus Penicillium paxilli Ma(G)K. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043799