Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions
Joint Authors
Bitto, Alessandra
Squadrito, Francesco
Pizzino, Gabriele
Irrera, Natasha
Pallio, Giovanni
Mecchio, Anna
Galfo, Federica
Altavilla, Domenica
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Flavonoids, from Scutellaria baicalensis (Chinese skullcap) and Acacia catechu (black catechu), have been shown to exert a variety of therapeutic effects, including anti-inflammatory, antiviral, antibacterial, and anticancer activities.
Flavocoxid is a mixed extract containing baicalin and catechin and it acts as a dual balanced inhibitor of cyclooxygenase-1 (COX-1) and COX-2 peroxidase enzyme activities with a significant inhibition of 5-lipoxygenase (5-LOX) enzyme activity in vitro.
Flavocoxid downregulates gene or protein expression of several inflammatory markers and exerts also strong antioxidant activity in several experimental models.
Controlled clinical trials and a postmarketing study have clearly shown that flavocoxid is as effective as naproxen in managing the signs and symptoms of osteoarthritis of the knee and it has better upper gastrointestinal, renal, and respiratory safety profile than naproxen.
Flavocoxid may therefore provide a potential therapeutic approach to the treatment of chronic inflammatory conditions.
American Psychological Association (APA)
Bitto, Alessandra& Squadrito, Francesco& Pallio, Giovanni& Mecchio, Anna& Galfo, Federica& Altavilla, Domenica…[et al.]. 2014. Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043807
Modern Language Association (MLA)
Pallio, Giovanni…[et al.]. Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043807
American Medical Association (AMA)
Bitto, Alessandra& Squadrito, Francesco& Pallio, Giovanni& Mecchio, Anna& Galfo, Federica& Altavilla, Domenica…[et al.]. Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043807