Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas’ Heart Disease
Joint Authors
Pereira, Isabela Resende
Vilar-Pereira, Glaucia
Silva, Andrea Alice
Moreira, Otacilio Cruz
Britto, Constança
Sarmento, Ellen Diana Marinho
Lannes-Vieira, Joseli
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Background.
Chagas disease (CD) is characterized by parasite persistence and immunological unbalance favoring systemic inflammatory profile.
Chronic chagasic cardiomyopathy, the main manifestation of CD, occurs in a TNF-enriched milieu and frequently progresses to heart failure.
Aim of the Study.
To challenge the hypothesis that TNF plays a key role in Trypanosoma cruzi-induced immune deregulation and cardiac abnormalities, we tested the effect of the anti-TNF antibody Infliximab in chronically T.
cruzi-infected C57BL/6 mice, a model with immunological, electrical, and histopathological abnormalities resembling Chagas’ heart disease.
Results.
Infliximab therapy did not reactivate parasite but reshaped the immune response as reduced TNF mRNA expression in the cardiac tissue and plasma TNF and IFNγ levels; diminished the frequency of IL-17A+ but increased IL-10+ CD4+ T-cells; reduced TNF+ but augmented IL-10+ Ly6C+ and F4/80+ cells.
Further, anti-TNF therapy decreased cytotoxic activity but preserved IFNγ-producing VNHRFTLV-specific CD8+ T-cells in spleen and reduced the number of perforin+ cells infiltrating the myocardium.
Importantly, Infliximab reduced the frequency of mice afflicted by arrhythmias and second degree atrioventricular blocks and decreased fibronectin deposition in the cardiac tissue.
Conclusions.
Our data support that TNF is a crucial player in the pathogenesis of Chagas’ heart disease fueling immunological unbalance which contributes to cardiac abnormalities.
American Psychological Association (APA)
Pereira, Isabela Resende& Vilar-Pereira, Glaucia& Silva, Andrea Alice& Moreira, Otacilio Cruz& Britto, Constança& Sarmento, Ellen Diana Marinho…[et al.]. 2014. Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas’ Heart Disease. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1043810
Modern Language Association (MLA)
Pereira, Isabela Resende…[et al.]. Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas’ Heart Disease. Mediators of Inflammation No. 2014 (2014), pp.1-16.
https://search.emarefa.net/detail/BIM-1043810
American Medical Association (AMA)
Pereira, Isabela Resende& Vilar-Pereira, Glaucia& Silva, Andrea Alice& Moreira, Otacilio Cruz& Britto, Constança& Sarmento, Ellen Diana Marinho…[et al.]. Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas’ Heart Disease. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-16.
https://search.emarefa.net/detail/BIM-1043810
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043810