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Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control
Joint Authors
Sangiuliano, Beatriz
Pérez, Nancy Marcela
Moreira, Dayson F.
Belizário, José E.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell stress, injury, and chemotherapeutics exposure.
Dying and death cells release a variety of self-proteins and bioactive chemicals originated from cytosol, nucleus, endoplasmic reticulum, and mitochondria.
These endogenous factors are named cell death-associated molecular-pattern (CDAMP), damage-associated molecular-pattern (DAMP) molecules, and alarmins.
Some of them cooperate or act as important initial or delayed inflammatory mediators upon binding to diverse membrane and cytosolic receptors coupled to signaling pathways for the activation of the inflammasome platforms and NF-κB multiprotein complexes.
Current studies show that the nonprotein thiols and thiol-regulating enzymes as well as highly diffusible prooxidant reactive oxygen and nitrogen species released together in extracellular inflammatory milieu play essential role in controlling pro- and anti-inflammatory activities of CDAMP/DAMP and alarmins.
Here, we provide an overview of these emerging concepts and mechanisms of triggering and maintenance of tissue inflammation under massive death of cells.
American Psychological Association (APA)
Sangiuliano, Beatriz& Pérez, Nancy Marcela& Moreira, Dayson F.& Belizário, José E.. 2014. Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043831
Modern Language Association (MLA)
Sangiuliano, Beatriz…[et al.]. Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control. Mediators of Inflammation No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1043831
American Medical Association (AMA)
Sangiuliano, Beatriz& Pérez, Nancy Marcela& Moreira, Dayson F.& Belizário, José E.. Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1043831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043831