Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation
Joint Authors
Perez, Denise Alves
Vago, Juliana Priscila
Athayde, Rayssa Maciel
Reis, Alesandra Corte
Sousa, Lirlândia Pires
Pinho, Vanessa
Teixeira, Mauro Martins
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Inflammation is a physiological response of the immune system to injury or infection but may become chronic.
In general, inflammation is self-limiting and resolves by activating a termination program named resolution of inflammation.
It has been argued that unresolved inflammation may be the basis of a variety of chronic inflammatory diseases.
Resolution of inflammation is an active process that is fine-tuned by the production of proresolving mediators and the shutdown of intracellular signaling molecules associated with cytokine production and leukocyte survival.
Apoptosis of leukocytes (especially granulocytes) is a key element in the resolution of inflammation and several signaling molecules are thought to be involved in this process.
Here, we explore key signaling molecules and some mediators that are crucial regulators of leukocyte survival in vivo and that may be targeted for therapeutic purposes in the context of chronic inflammatory diseases.
American Psychological Association (APA)
Perez, Denise Alves& Vago, Juliana Priscila& Athayde, Rayssa Maciel& Reis, Alesandra Corte& Teixeira, Mauro Martins& Sousa, Lirlândia Pires…[et al.]. 2014. Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043836
Modern Language Association (MLA)
Perez, Denise Alves…[et al.]. Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043836
American Medical Association (AMA)
Perez, Denise Alves& Vago, Juliana Priscila& Athayde, Rayssa Maciel& Reis, Alesandra Corte& Teixeira, Mauro Martins& Sousa, Lirlândia Pires…[et al.]. Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043836