Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy
Joint Authors
Kawada, Teruo
Yu, Rina
Le, Ngoc Hoan
Yoon Park, Jung Han
Park, Taesun
Sung, M.-K.
Kim, Chu-Sook
Hong, Sun-Myung
Choe, Suck-Young
Goto, Tsuyoshi
Lee, Dong Gun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Skeletal muscle inflammation and atrophy are closely associated with metabolic impairment such as insulin resistance.
Quercetin, a natural polyphenol flavonoid, is known to elicit anti-inflammatory and antioxidant activities.
In this study, we investigated its effect on obesity-induced skeletal muscle inflammation and atrophy in mice.
Male C57BL/6 mice were fed a regular diet, a high-fat diet (HFD), and an HFD supplemented with quercetin for nine weeks.
Quercetin reduced levels of inflammatory cytokines and macrophage accumulation in the skeletal muscle of the HFD-fed obese mice.
It also reduced transcript and protein levels of the specific atrophic factors, Atrogin-1 and MuRF1, in the skeletal muscle of the HFD-fed obese mice, and protected against the reduction of muscle mass and muscle fiber size.
In vitro, quercetin markedly diminished transcript levels of inflammatory receptors and activation of their signaling molecules (ERK, p38 MAPK, and NF- κ B) in cocultured myotubes/macrophages, and this was accompanied by reduced expression of the atrophic factors.
Together, these findings suggest that quercetin reduces obesity-induced skeletal muscle atrophy by inhibiting inflammatory receptors and their signaling pathway.
Quercetin may be useful for preventing obesity-induced muscle inflammation and sarcopenia.
American Psychological Association (APA)
Le, Ngoc Hoan& Kim, Chu-Sook& Park, Taesun& Yoon Park, Jung Han& Sung, M.-K.& Lee, Dong Gun…[et al.]. 2014. Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043838
Modern Language Association (MLA)
Le, Ngoc Hoan…[et al.]. Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043838
American Medical Association (AMA)
Le, Ngoc Hoan& Kim, Chu-Sook& Park, Taesun& Yoon Park, Jung Han& Sung, M.-K.& Lee, Dong Gun…[et al.]. Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043838