Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy

Joint Authors

Kawada, Teruo
Yu, Rina
Le, Ngoc Hoan
Yoon Park, Jung Han
Park, Taesun
Sung, M.-K.
Kim, Chu-Sook
Hong, Sun-Myung
Choe, Suck-Young
Goto, Tsuyoshi
Lee, Dong Gun

Source

Mediators of Inflammation

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-12-28

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

Skeletal muscle inflammation and atrophy are closely associated with metabolic impairment such as insulin resistance.

Quercetin, a natural polyphenol flavonoid, is known to elicit anti-inflammatory and antioxidant activities.

In this study, we investigated its effect on obesity-induced skeletal muscle inflammation and atrophy in mice.

Male C57BL/6 mice were fed a regular diet, a high-fat diet (HFD), and an HFD supplemented with quercetin for nine weeks.

Quercetin reduced levels of inflammatory cytokines and macrophage accumulation in the skeletal muscle of the HFD-fed obese mice.

It also reduced transcript and protein levels of the specific atrophic factors, Atrogin-1 and MuRF1, in the skeletal muscle of the HFD-fed obese mice, and protected against the reduction of muscle mass and muscle fiber size.

In vitro, quercetin markedly diminished transcript levels of inflammatory receptors and activation of their signaling molecules (ERK, p38 MAPK, and NF- κ B) in cocultured myotubes/macrophages, and this was accompanied by reduced expression of the atrophic factors.

Together, these findings suggest that quercetin reduces obesity-induced skeletal muscle atrophy by inhibiting inflammatory receptors and their signaling pathway.

Quercetin may be useful for preventing obesity-induced muscle inflammation and sarcopenia.

American Psychological Association (APA)

Le, Ngoc Hoan& Kim, Chu-Sook& Park, Taesun& Yoon Park, Jung Han& Sung, M.-K.& Lee, Dong Gun…[et al.]. 2014. Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043838

Modern Language Association (MLA)

Le, Ngoc Hoan…[et al.]. Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043838

American Medical Association (AMA)

Le, Ngoc Hoan& Kim, Chu-Sook& Park, Taesun& Yoon Park, Jung Han& Sung, M.-K.& Lee, Dong Gun…[et al.]. Quercetin Protects against Obesity-Induced Skeletal Muscle Inflammation and Atrophy. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043838

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1043838